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TargetPlatelet activating factor receptor
LigandBDBM50011631
Substrate/Competitorn/a
Meas. Tech.ChEBML_56498
IC50 5±n/a nM
Citation Walser AFlynn TMason CCrowley HMaresca CYaremko BO'Donnell M Triazolobenzo- and triazolothienodiazepines as potent antagonists of platelet activating factor. J Med Chem 34:1209-21 (1991) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Platelet activating factor receptor
Name:Platelet activating factor receptor
Synonyms:PAF Platelet activating factor | PAF-R | Platelet-activating factor receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:39219.60
Organism:Homo sapiens (Human)
Description:PAF Platelet activating factor PTAFR HUMAN::P25105
Residue:342
Sequence:
MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLT
MADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVT
RPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKG
SVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAV
FIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKF
RKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50011631
n/a
NameBDBM50011631
Synonyms:2-{3-[6-(2-Fluoro-phenyl)-1-trifluoromethyl-4H-2,3,5,10b-tetraaza-benzo[e]azulen-8-yl]-prop-2-ynyl}-isoindole-1,3-dione | CHEMBL20194
TypeSmall organic molecule
Emp. Form.C28H15F4N5O2
Mol. Mass.529.4446
SMILESFc1ccccc1C1=NCc2nnc(n2-c2ccc(cc12)C#CCN1C(=O)c2ccccc2C1=O)C(F)(F)F |t:8|
Structure
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