| Reaction Details |
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 | Report a problem with these data |
| Target | Gag-Pol polyprotein [489-587] |
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| Ligand | BDBM50005687 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_158641 (CHEMBL763428) |
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| IC50 | 51±n/a nM |
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| Citation |  Rich, DH; Sun, CQ; Vara Prasad, JV; Pathiasseril, A; Toth, MV; Marshall, GR; Clare, M; Mueller, RA; Houseman, K Effect of hydroxyl group configuration in hydroxyethylamine dipeptide isosteres on HIV protease inhibition. Evidence for multiple binding modes. J Med Chem34:1222-5 (1991) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Gag-Pol polyprotein [489-587] |
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| Name: | Gag-Pol polyprotein [489-587] |
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| Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 10781.16 |
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| Organism: | Human immunodeficiency virus type 1 |
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| Description: | P04585[489-587] |
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| Residue: | 99 |
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| Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
|
|
|
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| BDBM50005687 |
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| n/a |
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| Name | BDBM50005687 |
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| Synonyms: | 1-[3-(2-Benzyloxycarbonylamino-3-carbamoyl-propionylamino)-2-hydroxy-4-phenyl-butyl]-pyrrolidine-2-carboxylic acid tert-butyl ester | BDBM50010502 | CHEMBL115292 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H42N4O7 |
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| Mol. Mass. | 582.6878 |
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| SMILES | CC(C)(C)OC(=O)[C@@H]1CCCN1C[C@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)OCc1ccccc1 |
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| Structure | 
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