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Reaction Details
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TargetThymidylate synthase
LigandBDBM50011754
Substrate/Competitorn/a
Meas. Tech.ChEBML_209808
IC50 260±n/a nM
Citation Thornton, TJJones, TRJackman, ALFlinn, AO'Connor, BMWarner, PCalvert, AH Quinazoline antifolates inhibiting thymidylate synthase: 4-thio-substituted analogues. J Med Chem34:978-84 (1991) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Thymidylate synthase
Name:Thymidylate synthase
Synonyms:TS | TSase | TYSY_MOUSE | Tyms
Type:PROTEIN
Mol. Mass.:34957.15
Organism:Mus musculus
Description:ChEMBL_1340097
Residue:307
Sequence:
MLVVGSELQSDAQQLSAEAPRHGELQYLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYS
LRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSAR
QEGDLGPVYGFQWRHFGAEYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKD
LPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPG
DFVHTLGDAHIYLNHIEPLKIQLQREPRPFPKLKILRKVETIDDFKVEDFQIEGYNPHPT
IKMEMAV
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  Blast E-value cutoff:
BDBM50011754
n/a
NameBDBM50011754
Synonyms:2-{4-[Ethyl-(4-thioxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid | CHEMBL369718
TypeSmall organic molecule
Emp. Form.C23H24N4O5S
Mol. Mass.468.525
SMILESCCN(Cc1ccc2nc[nH]c(=S)c2c1)c1ccc(cc1)C(=O)NC(CCC(O)=O)C(O)=O
Structure
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