Reaction Details |
| Report a problem with these data |
Target | Thymidylate synthase |
---|
Ligand | BDBM50011754 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_209808 |
---|
IC50 | 260±n/a nM |
---|
Citation | Thornton, TJ; Jones, TR; Jackman, AL; Flinn, A; O'Connor, BM; Warner, P; Calvert, AH Quinazoline antifolates inhibiting thymidylate synthase: 4-thio-substituted analogues. J Med Chem34:978-84 (1991) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Thymidylate synthase |
---|
Name: | Thymidylate synthase |
Synonyms: | TS | TSase | TYSY_MOUSE | Tyms |
Type: | PROTEIN |
Mol. Mass.: | 34957.15 |
Organism: | Mus musculus |
Description: | ChEMBL_1340097 |
Residue: | 307 |
Sequence: | MLVVGSELQSDAQQLSAEAPRHGELQYLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYS
LRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSAR
QEGDLGPVYGFQWRHFGAEYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKD
LPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPG
DFVHTLGDAHIYLNHIEPLKIQLQREPRPFPKLKILRKVETIDDFKVEDFQIEGYNPHPT
IKMEMAV
|
|
|
BDBM50011754 |
---|
n/a |
---|
Name | BDBM50011754 |
Synonyms: | 2-{4-[Ethyl-(4-thioxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid | CHEMBL369718 |
Type | Small organic molecule |
Emp. Form. | C23H24N4O5S |
Mol. Mass. | 468.525 |
SMILES | CCN(Cc1ccc2nc[nH]c(=S)c2c1)c1ccc(cc1)C(=O)NC(CCC(O)=O)C(O)=O |
Structure |
|