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TargetChymotrypsin-like elastase family member 1/2A
LigandBDBM50014736
Substrate/Competitorn/a
Meas. Tech.ChEMBL_64822 (CHEMBL678403)
Ki 32±n/a nM
Citation Peet, NPBurkhart, JPAngelastro, MRGiroux, ELMehdi, SBey, PKolb, MNeises, BSchirlin, D Synthesis of peptidyl fluoromethyl ketones and peptidyl alpha-keto esters as inhibitors of porcine pancreatic elastase, human neutrophil elastase, and rat and human neutrophil cathepsin G. J Med Chem33:394-407 (1990) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Chymotrypsin-like elastase family member 1/2A
Name:Chymotrypsin-like elastase family member 1/2A
Synonyms:Pancreatic elastase
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 152345
Components:This complex has 2 components.
Component 1
Name:Chymotrypsin-like elastase family member 1
Synonyms:CELA1 | CELA1_PIG | ELA1 | Elastase | Elastase 1 | Elastase-1 | Pancreatic elastase
Type:Enzyme
Mol. Mass.:28827.71
Organism:Sus scrofa (Pig)
Description:P00772
Residue:266
Sequence:
MLRLLVVASLVLYGHSTQDFPETNARVVGGTEAQRNSWPSQISLQYRSGSSWAHTCGGTL
IRQNWVMTAAHCVDRELTFRVVVGEHNLNQNDGTEQYVGVQKIVVHPYWNTDDVAAGYDI
ALLRLAQSVTLNSYVQLGVLPRAGTILANNSPCYITGWGLTRTNGQLAQTLQQAYLPTVD
YAICSSSSYWGSTVKNSMVCAGGDGVRSGCQGDSGGPLHCLVNGQYAVHGVTSFVSRLGC
NVTRKPTVFTRVSAYISWINNVIASN
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Component 2
Name:Chymotrypsin-like elastase family member 2A
Synonyms:CEL2A_PIG | CELA2A | ELA2 | ELA2A | Elastase 2A | Elastase-2 | Elastase-2A | Pancreatic elastase
Type:PROTEIN
Mol. Mass.:28705.23
Organism:Sus scrofa
Description:ChEMBL_156951
Residue:269
Sequence:
MIRALLLSTLVAGALSCGLPANLPQLPRVVGGEDARPNSWPWQVSLQYDSSGQWRHTCGG
TLVDQSWVLTAAHCISSSRTYRVVLGRHSLSTNEPGSLAVKVSKLVVHQDWNSNQLSNGN
DIALLKLASPVSLTDKIQLGCLPAAGTILPNNYVCYVTGWGRLQTNGASPDILQQGQLLV
VDYATCSKPGWWGSTVKTNMICAGGDGIISSCNGDSGGPLNCQGANGQWQVHGIVSFGSS
LGCNYYHKPSVFTRVSNYIDWINSVIANN
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BDBM50014736
n/a
NameBDBM50014736
Synonyms:(1-{1-Methyl-2-oxo-2-[2-(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidin-1-yl]-ethylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester | CHEMBL337396
TypeSmall organic molecule
Emp. Form.C22H35F3N4O6
Mol. Mass.508.5317
SMILESCC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)OC(C)(C)C)C(=O)C(F)(F)F
Structure
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