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TargetDihydrofolate reductase
LigandBDBM50024475
Substrate/Competitorn/a
Meas. Tech.ChEBML_54604
Ki>1000±n/a nM
Citation DeGraw, JIChristie, PHKisliuk, RLGaumont, YSirotnak, FM Synthesis and antifolate properties of 10-alkyl-5,10-dideaza analogues of methotrexate and tetrahydrofolic acid. J Med Chem33:673-7 (1990) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:DYR_MOUSE | Dhfr
Type:Enzyme
Mol. Mass.:21608.82
Organism:Mus musculus (Mouse)
Description:n/a
Residue:187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKF
EVYEKKD
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BDBM50024475
n/a
NameBDBM50024475
Synonyms:2-{4-[(2-Amino-4-oxo-1,4,5,6,7,8-hexahydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid | 2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid (H4-DDF) | CHEMBL279508
TypeSmall organic molecule
Emp. Form.C21H25N5O6
Mol. Mass.443.4531
SMILESNc1nc2CCC(CNc3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O)Cc2c(=O)[nH]1
Structure
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