| Reaction Details |
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 | Report a problem with these data |
| Target | 3-oxo-5-alpha-steroid 4-dehydrogenase 1/2 |
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| Ligand | BDBM50015844 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_210247 (CHEMBL883487) |
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| pH | 7.4±n/a |
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| Ki | 10000±n/a nM |
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| Comments | extracted |
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| Citation |  Jarman, M; Barrie, SE; Deadman, JJ; Houghton, J; McCague, R; Rowlands, MG Hydroxyperfluoroazobenzenes: novel inhibitors of enzymes of androgen biosynthesis. J Med Chem33:2452-5 (1990) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 1/2 |
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| Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1/2 |
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| Synonyms: | Steroid 5-alpha-reductase |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 204723 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
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| Synonyms: | S5A1_RAT | Srd5a1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 29788.29 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1441437 |
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| Residue: | 259 |
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| Sequence: | MVPLMELDELCLLDMLVYLEGFMAFVSIVGLRSVGSPYGRYSPQWPGIRVPARPAWFIQE
LPSMAWPLYEYIRPAAARLGNLPNRVLLAMFLIHYVQRTLVFPVLIRGGKPTLLVTFVLA
FLFCTFNGYVQSRYLSQFAVYAEDWVTHPCFLTGFALWLVGMVINIHSDHILRNLRKPGE
TGYKIPRGGLFEYVSAANYFGELVEWCGFALASWSLQGVVFALFTLSTLLTRAKQHHQWY
HEKFEDYPKSRKILIPFVL
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| Component 2 |
| Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 |
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| Synonyms: | S5A2_RAT | Srd5a2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 28784.15 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_205054 |
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| Residue: | 254 |
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| Sequence: | MQIVCHQVPVLAGSATLATMGTLILCLGKPASYGKHTESVSSGVPFLPARIAWFLQELPS
FVVSVGMLAWQPRSLFGPPGNVLLALFSAHYFHRTFIYSLLTRGRPFPAVLFLRATAFCI
GNGLLQAYYLVYCAEYPEEWYTDVRFSFGVFLFILGMGINIHSDYTLRQLRKPGEVIYRI
PRGGLFTYVSGANFLGEIIEWIGYALATWSVPAFAFAFFTLCFLGMQAFYHHRFYLKMFK
DYPKSRKALIPFIF
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| BDBM50015844 |
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| n/a |
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| Name | BDBM50015844 |
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| Synonyms: | 2,3,5,6-Tetrafluoro-4-pentafluorophenylazo-phenol | CHEMBL309703 |
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| Type | Small organic molecule |
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| Emp. Form. | C12HF9N2O |
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| Mol. Mass. | 360.1348 |
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| SMILES | Oc1c(F)c(F)c(N=Nc2c(F)c(F)c(F)c(F)c2F)c(F)c1F |w:8.8| |
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| Structure | 
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