Reaction Details |
| Report a problem with these data |
Target | Neprilysin |
---|
Ligand | BDBM50016766 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_144455 |
---|
IC50 | 11±n/a nM |
---|
Citation | Haslanger, MF; Sybertz, EJ; Neustadt, BR; Smith, EM; Nechuta, TL; Berger, J Carboxyalkyl dipeptides with atrial natriuretic factor potentiating and antihypertensive activity. J Med Chem32:737-9 (1989) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Neprilysin |
---|
Name: | Neprilysin |
Synonyms: | Atriopeptidase | CD10 antigen | CD_antigen=CD10 | Enkephalinase | MME | NEP | NEP_RABIT | Neutral Endopeptidase | Neutral endopeptidase 24.11 |
Type: | Enzyme |
Mol. Mass.: | 85570.75 |
Organism: | Oryctolagus cuniculus (rabbit) |
Description: | NEP was purified to homogeneity from rabbit kidney. |
Residue: | 750 |
Sequence: | MGRSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTVIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDATAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKD
VLQEPKTEDIVAVQKAKTLYRSCVNETAIDSRGGQPLLKLLPDVYGWPVATQNWEQTYGT
SWSAEKSIAQLNSNYGKKVLINFFVGTDDKNSMNHIIHIDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMIAVAKLIRQEEGLPIDENQISVEMNKVMELEKEIANATTKSEDRNDPMLLY
NKMTLAQIQNNFSLEINGKPFSWSNFTNEIMSTVNINIPNEEDVVVYAPEYLIKLKPILT
KYFPRDFQNLFSWRFIMDLVSSLSRTYKDSRNAFRKALYGTTSESATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERI
GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWITGAA
IVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSANNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGIGQAYR
AYQNYVKKNGEEKLLPGIDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GSLQNSVEFSEAFQCPKNSYMNPEKKCRVW
|
|
|
BDBM50016766 |
---|
n/a |
---|
Name | BDBM50016766 |
Synonyms: | 2-[1-(2-Carboxy-2-hydroxy-ethylcarbamoyl)-2-phenyl-ethylamino]-3-phenyl-propionic acid | CHEMBL163635 |
Type | Small organic molecule |
Emp. Form. | C21H24N2O6 |
Mol. Mass. | 400.4251 |
SMILES | O[C@@H](CNC(=O)[C@H](Cc1ccccc1)N[C@@H](Cc1ccccc1)C(O)=O)C(O)=O |
Structure |
|