Reaction Details |
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Target | Mu-type opioid receptor |
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Ligand | BDBM50016862 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_148847 (CHEMBL753964) |
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Ki | 2200±n/a nM |
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Citation | Schiller, PW; Nguyen, TM; Chung, NN; Lemieux, C Dermorphin analogues carrying an increased positive net charge in their"message" domain display extremely high mu opioid receptor selectivity. J Med Chem32:698-703 (1989) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Mu-type opioid receptor |
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Name: | Mu-type opioid receptor |
Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 44503.11 |
Organism: | Rattus norvegicus (rat) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. |
Residue: | 398 |
Sequence: | MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
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BDBM50016862 |
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n/a |
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Name | BDBM50016862 |
Synonyms: | 5-Amino-2-(2-{2-[2-amino-3-(4-hydroxy-phenyl)-propionylamino]-pentanoylamino}-3-phenyl-propionylamino)-pentanoic acid amide | CHEMBL2371285 |
Type | Small organic molecule |
Emp. Form. | C28H40N6O5 |
Mol. Mass. | 540.6544 |
SMILES | CCC[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN)C(N)=O |
Structure |
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