| Reaction Details |
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 | Report a problem with these data |
| Target | D(1A)/D(2) dopamine receptor |
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| Ligand | BDBM50016894 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_59580 (CHEMBL672931) |
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| IC50 | 51±n/a nM |
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| Citation |  Hutchison, A; Williams, M; de Jesus, R; Stone, GA; Sylvester, L; Clarke, FH; Sills, MA 2H-[1]benzopyrano[3,4-b]pyridines: synthesis and activity at central monoamine receptors. J Med Chem32:720-7 (1989) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| D(1A)/D(2) dopamine receptor |
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| Name: | D(1A)/D(2) dopamine receptor |
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| Synonyms: | Dopamine receptor |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 59578 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | D(2) dopamine receptor |
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| Synonyms: | DOPAMINE D2 | DRD2 | DRD2_BOVIN | Dopamine D2 receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 50698.79 |
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| Organism: | BOVINE |
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| Description: | P20288 |
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| Residue: | 444 |
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| Sequence: | MDPLNLSWYDDDPESRNWSRPFNGSEGKADRPPYNYYAMLLTLLIFVIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPMLFGLNNTDQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRANLKAPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKTVNPKIAKIFEIQSMPNGKTRTSLKTMS
RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNS
AVNPIIYTTFNIEFRKAFLKILHC
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| Component 2 |
| Name: | D(1A) dopamine receptor |
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| Synonyms: | D(1A) dopamine receptor | D1AR | DOPAMINE D1 | DRD1 | DRD1_BOVIN | Dopamine receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 49330.65 |
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| Organism: | BOVINE |
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| Description: | DOPAMINE D1 DRD1 BOVINE::Q95136 |
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| Residue: | 446 |
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| Sequence: | MRTLNTSTMEGTGLVAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD
RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTGPSEGNATSLG
KTINNCDSSLSRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISALERAAVHAKN
CQTTTGNGNPMECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCGS
GETKPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPTTNNAIET
VSINNNGAVVFSSHHEPRGSISKDCNVVYLIPHAVGSSEGLKKEEAVGIAKPLEKLSPAL
SVILDYDTDVSLEKIQPITQNGQHPT
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| BDBM50016894 |
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| n/a |
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| Name | BDBM50016894 |
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| Synonyms: | 1-Propyl-2,3,10,10a-tetrahydro-1H-9-oxa-1-aza-phenanthren-6-ol | CHEMBL163061 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H19NO2 |
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| Mol. Mass. | 245.3169 |
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| SMILES | CCCN1CCC=C2C1COc1ccc(O)cc21 |c:6| |
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| Structure | 
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