| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B |
|---|
| Ligand | BDBM50017096 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_43469 (CHEMBL659371) |
|---|
| IC50 | >1000000±n/a nM |
|---|
| Citation |  Marivet, MC; Bourguignon, JJ; Lugnier, C; Mann, A; Stoclet, JC; Wermuth, CG Inhibition of cyclic adenosine-3',5'-monophosphate phosphodiesterase from vascular smooth muscle by rolipram analogues. J Med Chem32:1450-7 (1989) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B |
|---|
| Name: | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B |
|---|
| Synonyms: | Phosphodiesterase 1 |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of ChEMBL is 156011 |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B |
|---|
| Synonyms: | 63 kDa Cam-PDE | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | Cam-PDE 1B | PDE1B | PDE1B1 | PDE1B_BOVIN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 60991.90 |
|---|
| Organism: | Bos taurus |
|---|
| Description: | ChEMBL_104913 |
|---|
| Residue: | 534 |
|---|
| Sequence: | MELSPRSPPEMLESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEVNIEELKKNLE
YTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQTRAKGPSEEKPKF
RSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNVDLWCFDVFSLNRAADDHALRT
IVFELLTRHNLISRFKIPTVFLMTFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRT
GMVHCLSEIEVLAIIFAAAIHDYEHTGTTNSFHIQTKSECAILYNDRSVLENHHISSVFR
MMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKSMKTALQQLERIDKSKAL
SLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQI
GFIDFIVEPTFSVLTDVAEKSVQPTGDDDSKSKNQPSFQWRQPSLDVEVGDPNPDVVSFR
STWTKYIQENKQKWKERAASGITNQMSIDELSPCEEEAPASPAEDEHNQNGNLD
|
|
|
|---|
| Component 2 |
| Name: | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A |
|---|
| Synonyms: | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A | Heart phosphodiesterase | PDE1A | PDE1A_BOVIN | Phosphodiesterase 1 | Phosphodiesterase 1A |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 60835.05 |
|---|
| Organism: | BOVINE |
|---|
| Description: | Phosphodiesterase 1 0 BOVINE::P14100 |
|---|
| Residue: | 530 |
|---|
| Sequence: | MGSTATETEELENTTFKYLIGEQTEKMWQRLKGILRCLVKQLEKGDVNVIDLKKNIEYAA
SVLEAVYIDETRRLLDTDDELSDIQSDSVPSEVRDWLASTFTRKMGMMKKKSEEKPRFRS
IVHVVQAGIFVERMYRKSYHMVGLAYPEAVIVTLKDVDKWSFDVFALNEASGEHSLKFMI
YELFTRYDLINRFKIPVSCLIAFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGI
MHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLM
QEEEMNVLINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGLDKAKTMSL
ILHAADISHPAKSWKLHHRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGF
IDFIVEPTFSLLTDSTEKIIIPLIEEDSKTKTPSYGASRRSNMKGTTNDGTYSPDYSLAS
VDLKSFKNSLVDIIQQNKERWKELAAQGEPDPHKNSDLVNAEEKHAETHS
|
|
|
|---|
| BDBM50017096 |
|---|
| n/a |
|---|
| Name | BDBM50017096 |
|---|
| Synonyms: | 4-(3-Benzyloxy-4-methoxy-phenyl)-pyrrolidin-2-one | CHEMBL289253 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H19NO3 |
|---|
| Mol. Mass. | 297.3484 |
|---|
| SMILES | COc1ccc(cc1OCc1ccccc1)C1CNC(=O)C1 |
|---|
| Structure | 
|
|---|
Search and Browse
