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TargetFolylpolyglutamate synthase, mitochondrial
LigandBDBM50018236
Substrate/Competitorn/a
Meas. Tech.ChEBML_68383
Ki 420±n/a nM
Citation Patil, SAShane, BFreisheim, JHSingh, SKHynes, JB Inhibition of mammalian folylpolyglutamate synthetase and human dihydrofolate reductase by 5,8-dideaza analogues of folic acid and aminopterin bearing a terminal L-ornithine. J Med Chem32:1559-65 (1989) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Folylpolyglutamate synthase, mitochondrial
Name:Folylpolyglutamate synthase, mitochondrial
Synonyms:FOLC_HUMAN | FPGS | Folylpoly-gamma-glutamate synthetase | Folylpolyglutamate synthase, mitochondrial | Tetrahydrofolate synthase | Tetrahydrofolylpolyglutamate synthase
Type:PROTEIN
Mol. Mass.:64621.95
Organism:Homo sapiens (Human)
Description:ChEMBL_68676
Residue:587
Sequence:
MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAG
YLEQVKRQRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVTGTKGKGSTCAFTECILRS
YGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHRLEETKDGSCVSMPPYFRF
LTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIA
WQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCPMLEALEEGGPPLTLGLEGE
HQRSNAALALQLAHCWLQRQDRHGAGEPKASRPGLLWQLPLAPVFQPTSHMRLGLRNTEW
PGRTQVLRRGPLTWYLDGAHTASSAQACVRWFRQALQGRERPSGGPEVRVLLFNATGDRD
PAALLKLLQPCQFDYAVFCPNLTEVSSTGNADQQNFTVTLDQVLLRCLEHQQHWNHLDEE
QASPDLWSAPSPEPGGSASLLLAPHPPHTCSASSLVFSCISHALQWISQGRDPIFQPPSP
PKGLLTHPVAHSGASILREAAAIHVLVTGSLHLVGGVLKLLEPALSQ
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  Blast E-value cutoff:
BDBM50018236
n/a
NameBDBM50018236
Synonyms:5-Amino-2-[4-(4-oxo-3,4-dihydro-quinazolin-6-ylmethylsulfanyl)-benzoylamino]-pentanoic acid | CHEMBL43288
TypeSmall organic molecule
Emp. Form.C21H22N4O4S
Mol. Mass.426.489
SMILESNCCCC(NC(=O)c1ccc(SCc2ccc3nc[nH]c(=O)c3c2)cc1)C(O)=O
Structure
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