Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50018469 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_53148 (CHEMBL665868) |
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Ki | 0.800000±n/a nM |
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Citation | Roth, B; Tidwell, MY; Ferone, R; Baccanari, DP; Sigel, CW; DeAngelis, D; Elwell, LP 2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 13. Some alkenyl derivatives with high in vitro activity against anaerobic organisms. J Med Chem32:1949-58 (1989) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 21453.99 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human DHFR. |
Residue: | 187 |
Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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BDBM50018469 |
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n/a |
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Name | BDBM50018469 |
Synonyms: | 5-(4-Methoxy-3,5-dipropenyl-benzyl)-pyrimidine-2,4-diamine | CHEMBL301030 |
Type | Small organic molecule |
Emp. Form. | C18H22N4O |
Mol. Mass. | 310.3935 |
SMILES | COc1c(\C=C\C)cc(Cc2cnc(N)nc2N)cc1\C=C\C |
Structure |
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