| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50018473 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_54421 (CHEMBL667179) |
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| Ki | 0.800000±n/a nM |
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| Citation |  Roth, B; Tidwell, MY; Ferone, R; Baccanari, DP; Sigel, CW; DeAngelis, D; Elwell, LP 2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 13. Some alkenyl derivatives with high in vitro activity against anaerobic organisms. J Med Chem32:1949-58 (1989) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | Dihydrofolate reductase (F31V) | dfrA17 |
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| Type: | n/a |
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| Mol. Mass.: | 17532.46 |
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| Organism: | Escherichia coli |
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| Description: | n/a |
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| Residue: | 157 |
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| Sequence: | MKISLISAVSESGVIGSGPDIPWSVKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYA
VVSKNGISSSNENVLVFPSIENALKELSKVTDHVYVSGGGQIYNSLIEKADIIHLSTVHV
EVEGDIKFPIMPENFNLVFEQFFMSNINYTYQIWKKG
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|
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| BDBM50018473 |
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| n/a |
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| Name | BDBM50018473 |
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| Synonyms: | 2-Allyl-4-(2,4-diamino-pyrimidin-5-ylmethyl)-6-methoxy-phenol | CHEMBL59416 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H18N4O2 |
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| Mol. Mass. | 286.329 |
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| SMILES | COc1cc(Cc2cnc(N)nc2N)cc(CC=C)c1O |
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| Structure | 
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