Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetDelta-type opioid receptor
LigandBDBM50452250
Substrate/Competitorn/a
Meas. Tech.ChEBML_145186
IC50 4320±n/a nM
Citation Gairin, JEMazarguil, HAlvinerie, PSaint-Pierre, SMeunier, JCCros, J Synthesis and biological activities of dynorphin A analogues with opioid antagonist properties. J Med Chem29:1913-7 (1986) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Delta-type opioid receptor
Name:Delta-type opioid receptor
Synonyms:D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:40382.98
Organism:Homo sapiens (Human)
Description:Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50452250
n/a
NameBDBM50452250
Synonyms:CHEMBL2373014
TypeSmall organic molecule
Emp. Form.C73H101N23O13
Mol. Mass.1508.7293
SMILESNCCCC[C@H](NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(O)=O |wU:16.24,41.51,5.5,wD:9.8,63.78,27.40,52.62,77.90,96.102,(25.1,-5.27,;24.22,-6.52,;22.68,-6.38,;21.79,-7.64,;20.26,-7.5,;19.37,-8.75,;17.84,-8.61,;16.95,-9.87,;17.59,-11.27,;15.41,-9.73,;14.63,-8.41,;13.12,-8.74,;12.98,-10.28,;14.4,-10.89,;14.74,-12.39,;16.21,-12.85,;13.61,-13.43,;12.14,-12.98,;11.8,-11.47,;10.33,-11.02,;9.99,-9.51,;8.52,-9.06,;8.18,-7.56,;7.38,-10.1,;13.95,-14.94,;12.81,-15.98,;11.34,-15.52,;13.15,-17.48,;12.02,-18.53,;10.55,-18.07,;10.06,-16.61,;8.52,-16.63,;8.06,-18.1,;6.66,-18.75,;6.52,-20.28,;7.78,-21.17,;9.18,-20.53,;9.32,-18.99,;14.62,-17.94,;15.76,-16.9,;15.42,-15.39,;17.23,-17.35,;17.57,-18.85,;16.43,-19.9,;16.77,-21.4,;15.64,-22.45,;15.98,-23.95,;14.85,-24.99,;17.45,-24.41,;18.36,-16.31,;19.83,-16.76,;20.17,-18.27,;20.96,-15.72,;20.62,-14.22,;21.75,-13.17,;21.41,-11.67,;22.54,-10.63,;22.2,-9.12,;23.33,-8.08,;20.73,-8.67,;22.43,-16.18,;23.56,-15.13,;23.22,-13.63,;25.03,-15.59,;25.37,-17.09,;24.24,-18.14,;22.73,-17.83,;21.98,-19.18,;23.02,-20.31,;22.88,-21.84,;24.14,-22.73,;25.54,-22.09,;25.68,-20.55,;24.42,-19.67,;26.16,-14.54,;27.63,-15,;27.97,-16.5,;28.76,-13.96,;28.43,-12.45,;26.95,-12,;25.82,-13.04,;24.35,-12.58,;24.01,-11.08,;25.14,-10.04,;26.62,-10.49,;30.23,-14.41,;31.37,-13.37,;31.03,-11.87,;32.84,-13.83,;33.97,-12.78,;35.44,-13.24,;35.78,-14.74,;36.57,-12.19,;38.04,-12.65,;39.17,-11.6,;38.83,-10.1,;40.64,-12.06,;40.98,-13.56,;41.77,-11.02,;43.24,-11.47,;44.38,-10.43,;45.85,-10.89,;46.19,-12.39,;47.66,-12.85,;45.05,-13.43,;43.58,-12.98,;20.01,-10.15,;19.13,-11.41,;21.55,-10.29,)|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: