Reaction Details |
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Target | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase/7-dehydrocholesterol reductase |
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Ligand | BDBM50020286 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_35744 |
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IC50 | 32±n/a nM |
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Citation | Ruenitz, PC; Arrendale, RF; Schmidt, WF; Thompson, CB; Nanavati, NT Phenolic metabolites of clomiphene: [(E,Z)-2-[4-(1,2-diphenyl-2-chlorovinyl)phenoxy]ethyl]diethylamine. Preparation, electrophilicity, and effects in MCF 7 breast cancer cells. J Med Chem32:192-7 (1989) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase/7-dehydrocholesterol reductase |
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Name: | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase/7-dehydrocholesterol reductase |
Synonyms: | Anti-estrogen binding site (AEBS) |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of EBI is 35744 |
Components: | This complex has 2 components. |
Component 1 |
Name: | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase |
Synonyms: | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase/Delta(24)-sterol reductase | 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase | Anti-estrogen binding site (AEBS) | Cholestenol Delta-isomerase | D8-D7 sterol isomerase | Delta(8)-Delta(7) sterol isomerase | EBP | EBP_HUMAN | Emopamil-binding protein |
Type: | PROTEIN |
Mol. Mass.: | 26358.51 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_873432 |
Residue: | 230 |
Sequence: | MTTNAGPLHPYWPQHLRLDNFVPNDRPTWHILAGLFSVTGVLVVTTWLLSGRAAVVPLGT
WRRLSLCWFAVCGFIHLVIEGWFVLYYEDLLGDQAFLSQLWKEYAKGDSRYILGDNFTVC
METITACLWGPLSLWVVIAFLRQHPLRFILQLVVSVGQIYGDVLYFLTEHRDGFQHGELG
HPLYFWFYFVFMNALWLVLPGVLVLDAVKHLTHAQSTLDAKATKAKSKKN
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Component 2 |
Name: | 7-dehydrocholesterol reductase |
Synonyms: | 7-DHC reductase | 7-dehydrocholesterol reductase | Anti-estrogen binding site (AEBS) | D7SR | DHCR7 | DHCR7_HUMAN | Putative sterol reductase SR-2 | Sterol Delta(7)-reductase |
Type: | PROTEIN |
Mol. Mass.: | 54508.42 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_864350 |
Residue: | 475 |
Sequence: | MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMA
CDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHK
FLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPL
LWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFN
GRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHD
HFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDL
FRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCL
ACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF
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BDBM50020286 |
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n/a |
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Name | BDBM50020286 |
Synonyms: | 4-{1-Chloro-2-[4-(2-diethylamino-ethoxy)-phenyl]-2-phenyl-vinyl}-2-methoxy-phenol | CHEMBL292185 |
Type | Small organic molecule |
Emp. Form. | C27H30ClNO3 |
Mol. Mass. | 451.985 |
SMILES | CCN(CC)CCOc1ccc(cc1)C(=C(\Cl)c1ccc(O)c(OC)c1)\c1ccccc1 |
Structure |
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