Reaction Details |
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Target | Sodium- and chloride-dependent GABA transporter 1/GABA transporter 2/GABA transporter 3/betaine transporter |
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Ligand | BDBM23183 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_177035 (CHEMBL779556) |
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IC50 | 320000±n/a nM |
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Citation | Krogsgaard-Larsen, P; Nielsen, L; Falch, E; Curtis, DR GABA agonists. Resolution, absolute stereochemistry, and enantioselectivity of (S)-(+)- and (R)-(-)-dihydromuscimol. J Med Chem28:1612-7 (1985) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Sodium- and chloride-dependent GABA transporter 1/GABA transporter 2/GABA transporter 3/betaine transporter |
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Name: | Sodium- and chloride-dependent GABA transporter 1/GABA transporter 2/GABA transporter 3/betaine transporter |
Synonyms: | GABA transporter |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 177939 |
Components: | This complex has 4 components. |
Component 1 |
Name: | Sodium- and chloride-dependent GABA transporter 3 |
Synonyms: | Gabt3 | Gat-3 | Gat-b | S6A11_RAT | Slc6a11 | Sodium- and chloride-dependent GABA transporter 3 | Solute carrier family 6 member 11 |
Type: | PROTEIN |
Mol. Mass.: | 69948.77 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_105007 |
Residue: | 627 |
Sequence: | MTAEQALPLGNGKAAEEARGSEALGGGGGGAAGTREARDKAVHERGHWNNKVEFVLSVAG
EIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRRV
CPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTEKCVEFQK
LNFSNYSHVSLQNATSPVMEFWERRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWK
GTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQ
IFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGV
PIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDM
YPKVFRRGYRRELLILALSIVSYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECV
CIGWVYGSNRFYDNIEDMIGYRPLSLIKWCWKVVTPGICAGIFIFFLVKYKPLKYNNVYT
YPAWGYGIGWLMALSSMLCIPLWIFIKLWKTEGTLPEKLQKLTVPSADLKMRGKLGASPR
MVTVNDCEAKVKGDGTISAITEKETHF
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Component 2 |
Name: | Sodium- and chloride-dependent GABA transporter 2 |
Synonyms: | GABA transporter | GABA transporter 2 | Gabt2 | Gat-2 | S6A13_RAT | Slc6a13 |
Type: | PROTEIN |
Mol. Mass.: | 68261.89 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_70051 |
Residue: | 602 |
Sequence: | MDNRVSGTTSNGETKPVCPVMEKVEEDGTLEREQWTNKMEFVLSVAGEIIGLGNVWRFPY
LCYKNGGGAFFIPYLIFLFTCGIPVFFLETALGQYTNQGGITAWRKICPIFEGIGYASQM
IVSLLNVYYIVVLAWALFYLFSSFTTDLPWGSCSHEWNTENCVEFQKTNNSLNVTSENAT
SPVIEFWERRVLKISDGIQHLGSLRWELVLCLLLAWIICYFCIWKGVKSTGKVVYFTATF
PYLMLVVLLIRGVTLPGAAQGIQFYLYPNITRLWDPQVWMDAGTQIFFSFAICLGCLTAL
GSYNKYHNNCYRDCVALCILNSSTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFI
AYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPRVFRKKNRREILI
LIVSVVSFFIGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGASRFYDNI
EDMIGYKPWPLIKYCWLFFTPAVCLATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALS
SMVCIPAWSIYKLRTLKGPLRERLRQLVCPAEDLPQKSQPELTSPATPMTSLLRLTELES
NC
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Component 3 |
Name: | Sodium- and chloride-dependent GABA transporter 1 |
Synonyms: | GABA transporter | Gabt1 | Gat-1 | Gat1 | SC6A1_RAT | Slc6a1 | Solute carrier family 6 member 1 |
Type: | PROTEIN |
Mol. Mass.: | 67006.26 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_1472611 |
Residue: | 599 |
Sequence: | MATDNSKVADGQISTEVSEAPVASDKPKTLVVKVQKKAGDLPDRDTWKGRFDFLMSCVGY
AIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAP
MFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLV
NTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWVLVYFCIWKGVGWTGKVV
YFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGL
GSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASG
PGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRR
ELFIAAVCIVSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRF
YDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLM
ALSSMVLIPGYMAYMFLTLKGSLKQRLQVMIQPSEDIVRPENGPEQPQAGSSASKEAYI
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Component 4 |
Name: | Sodium- and chloride-dependent betaine transporter |
Synonyms: | Na(+)/Cl(-) betaine/GABA transporter | S6A12_RAT | Slc6a12 | Sodium- and chloride-dependent betaine transporter | Solute carrier family 6 member 12 |
Type: | PROTEIN |
Mol. Mass.: | 69749.57 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_105007 |
Residue: | 614 |
Sequence: | MDRKVTVHEDGCPVVSWVPEEGEMMDQKDKDQVKDRGQWTNKMEFVLSVAGEIIGLGNVW
RFPYLCYKNGGGAFFIPYFIFFFSCGIPVFFLEVALGQYSSQGSVTAWRKICPLLQGIGM
ASVVIESYLNIYYIIILAWALFYLFSSFTWELPWTTCTNSWNTEHCVDFLNYSSTRAASY
SENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVY
FTATFPYLMLIILLIRGVTLPGAYQGIVFYLKPDLLRLKDPQVWMDAGTQIFFSFAICQG
CLTALGSYNKYHNNCYRDSIALCFLNSATSFVAGFVVFSILGFMAQEQGVPISEVAESGP
GLAFIAFPKAVTMMPLSQLWSCLFFLMLLFLGLDSQFVCMECLVTASMDMFPQQLRKRGR
RELLILAVAIVCYLMGLLLVTEGGMYIFQLFDYYASSGICLLFLSLFEVICIGWVYGADR
FYDNVEDMIGYRPWPLVKISWLFLTPGLCLATFFFSLSKYTPLKYNNVYIYPSWGYSIGW
LLAFSSMACVPLFIIITLLKTQGSFKKRLQRLITPDPSLPQPGRRSPQDGSSAQNCSTSP
VKQELIAWEKETHL
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BDBM23183 |
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n/a |
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Name | BDBM23183 |
Synonyms: | 5-(aminomethyl)-1,2-oxazol-3-ol | Agarin | CHEMBL273481 | Muscimol | Pantherine |
Type | GABA Agonist |
Emp. Form. | C4H6N2O2 |
Mol. Mass. | 114.1026 |
SMILES | NCc1cc(=O)[nH]o1 |
Structure |
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