| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-lactamase TEM |
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| Ligand | BDBM50021956 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_40226 (CHEMBL653999) |
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| IC50 | 690±n/a nM |
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| Citation |  Micetich, RG; Maiti, SN; Spevak, P; Hall, TW; Yamabe, S; Ishida, N; Tanaka, M; Yamazaki, T; Nakai, A; Ogawa, K Synthesis and beta-lactamase inhibitory properties of 2 beta-[(1,2,3-triazol-1-yl)methyl]-2 alpha-methylpenam-3 alpha-carboxylic acid 1,1-dioxide and related triazolyl derivatives. J Med Chem30:1469-74 (1987) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-lactamase TEM |
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| Name: | Beta-lactamase TEM |
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| Synonyms: | BLAT_ECOLX | Bacterial beta-lactamase TEM | Beta-lactamase (TEM-1) | Beta-lactamase TEM | Beta-lactamase TEM-1 | Beta-lactamase TEM-1b | Beta-lactamase TEM1D | Beta-lactamase TEM1E | Beta-lactamase TEM1F | TEM beta lactamase | TEM extended-spectrum beta-lactamase | TEM-1 beta-lactamase | bla |
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| Type: | Enzyme |
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| Mol. Mass.: | 31512.33 |
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| Organism: | Escherichia coli |
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| Description: | P62593 |
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| Residue: | 286 |
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| Sequence: | MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRP
EERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVREL
CSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTM
PAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGS
RGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
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| BDBM50021956 |
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| n/a |
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| Name | BDBM50021956 |
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| Synonyms: | CHEMBL285387 | Sodium; 3-methyl-2,2,6-trioxo-3-[1,2,3]triazol-1-ylmethyl-2lambda*6*-thia-bicyclo[3.2.0]heptane-4-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C11H12N3O5S |
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| Mol. Mass. | 298.296 |
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| SMILES | C[C@]1(Cn2ccnn2)[C@@H](C2C(CC2=O)S1(=O)=O)C([O-])=O |
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| Structure | 
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