| Reaction Details |
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 | Report a problem with these data |
| Target | DNA topoisomerase 3 |
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| Ligand | BDBM50022163 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_54523 (CHEMBL663870) |
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| Ki | 400±n/a nM |
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| Citation |  Trantolo, DJ; Wright, GE; Brown, NC Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines. J Med Chem29:676-81 (1986) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA topoisomerase 3 |
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| Name: | DNA topoisomerase 3 |
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| Synonyms: | DNA topoisomerase III | TOP3_BACSU | topB |
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| Type: | PROTEIN |
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| Mol. Mass.: | 81515.22 |
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| Organism: | Bacillus subtilis |
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| Description: | ChEMBL_54525 |
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| Residue: | 727 |
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| Sequence: | MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDQYIVTWALGHLVTLADPEGYGKEFQS
WRLEDLPIIPEPLKLVVIKKTGKQFNAVKSQLTRKDVNQIVIATDAGREGELVARWIIEK
ANVRKPIKRLWISSVTDKAIKEGFQKLRSGKEYENLYHSAVARAEADWIVGINATRALTT
KFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGIRAAVDGMTLTWQDKKSKQTRTFN
QDVTSRLLKNLQGKQAVVAELKKTAKKSFAPALYDLTELQRDAHKRFGFSAKETLSVLQK
LYEQHKLVTYPRTDSRFLSSDIVPTLKDRLEGMEVKPYAQYVSQIKKRGIKSHKGYVNDA
KVSDHHAIIPTEEPLVLSSLSDKERKLYDLIAKRFLAVLMPAFEYEETKVIAEIGGETFT
AKGKTVQSQGWKAVYDMAEEDDEQEDDRDQTLPALQKGDTLAVRTLTETSGQTKPPARFN
EGTLLSAMENPSAFMQGEEKGLVKTLGETGGLGTVATRADIIEKLFNSFLIEKKGQDIFI
TSKGKQLLQLVPEDLKSPALTAEWEQKLSAIAAGKLKSAVFIKDMKAYAHQTVKEIKNSS
QTFRHDNITGTACPECGKMMLKVNGKRGTMLVCQDRECGSRKTIARKTNARCPNCHKRME
LRGQGEGQTFACVCGHREKLSVFEKRKNKDKARATKRDVSSYMKKQNKDEPINNALAEQL
KKLGLDK
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| BDBM50022163 |
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| n/a |
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| Name | BDBM50022163 |
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| Synonyms: | 6-(Indan-5-ylamino)-1H-pyrimidine-2,4-dione | CHEMBL54950 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H13N3O2 |
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| Mol. Mass. | 243.2612 |
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| SMILES | O=c1cc(Nc2ccc3CCCc3c2)[nH]c(=O)[nH]1 |
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| Structure | 
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