| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Renin-1 |
|---|
| Ligand | BDBM50022867 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_196286 |
|---|
| IC50 | 400±n/a nM |
|---|
| Citation |  Sham, HL; Bolis, G; Stein, HH; Fesik, SW; Marcotte, PA; Plattner, JJ; Rempel, CA; Greer, J Renin inhibitors. Design and synthesis of a new class of conformationally restricted analogues of angiotensinogen. J Med Chem31:284-95 (1988) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Renin-1 |
|---|
| Name: | Renin-1 |
|---|
| Synonyms: | Angiotensinogenase | Kidney renin | RENI1_MOUSE | Ren | Ren-1 | Ren1 | Renin | Renin-1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 44345.30 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_685608 |
|---|
| Residue: | 402 |
|---|
| Sequence: | MDRRRMPLWALLLLWSPCTFSLPTRTATFERIPLKKMPSVREILEERGVDMTRLSAEWGV
FTKRPSLTNLTSPVVLTNYLNTQYYGEIGIGTPPQTFKVIFDTGSANLWVPSTKCSRLYL
ACGIHSLYESSDSSSYMENGSDFTIHYGSGRVKGFLSQDSVTVGGITVTQTFGEVTELPL
IPFMLAKFDGVLGMGFPAQAVGGVTPVFDHILSQGVLKEEVFSVYYNRGSHLLGGEVVLG
GSDPQHYQGNFHYVSISKTDSWQITMKGVSVGSSTLLCEEGCAVVVDTGSSFISAPTSSL
KLIMQALGAKEKRIEEYVVNCSQVPTLPDISFDLGGRAYTLSSTDYVLQYPNRRDKLCTL
ALHAMDIPPPTGPVWVLGATFIRKFYTEFDRHNNRIGFALAR
|
|
|
|---|
| BDBM50022867 |
|---|
| n/a |
|---|
| Name | BDBM50022867 |
|---|
| Synonyms: | 2-[2-(2-{[7-(2-tert-Butoxycarbonylamino-3-phenyl-propionyl)-6-methyl-5-oxo-1-oxa-4,7-diaza-cyclododecane-3-carbonyl]-amino}-3-methyl-butyrylamino)-3-methyl-pentanoylamino]-3-(3H-imidazol-4-yl)-propionic acid methyl ester | CHEMBL97865 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C43H66N8O10 |
|---|
| Mol. Mass. | 855.0317 |
|---|
| SMILES | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H]1COCCCCCN([C@H](C)C(=O)N1)C(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)OC |
|---|
| Structure | 
|
|---|
Search and Browse
