Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma
LigandBDBM50023331
Substrate/Competitorn/a
Meas. Tech.ChEMBL_143081 (CHEMBL748731)
IC50 0.100000±n/a nM
Citation Kanne, DB; Abood, LG Synthesis and biological characterization of pyridohomotropanes. Structure-activity relationships of conformationally restricted nicotinoids. J Med Chem31:506-9 (1988) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Acetylcholine receptor subunit alpha/beta/delta/gamma
Name:Acetylcholine receptor subunit alpha/beta/delta/gamma
Synonyms:Acetylcholine receptor | Acetylcholine receptor protein alpha/beta/delta/gamma chain
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of EBI is 143080
Components:This complex has 4 components.
Component 1
Name:Acetylcholine receptor subunit beta
Synonyms:ACHB_TETCF | Acetylcholine receptor | CHRNB1
Type:PROTEIN
Mol. Mass.:56146.98
Organism:Torpedo californica
Description:EBI_19626
Residue:493
Sequence:
MENVRRMALGLVVMMALALSGVGASVMEDTLLSVLFETYNPKVRPAQTVGDKVTVRVGLT
LTNLLILNEKIEEMTTNVFLNLAWTDYRLQWDPAAYEGIKDLRIPSSDVWQPDIVLMNNN
DGSFEITLHVNVLVQHTGAVSWQPSAIYRSSCTIKVMYFPFDWQNCTMVFKSYTYDTSEV
TLQHALDAKGEREVKEIVINKDAFTENGQWSIEHKPSRKNWRSDDPSYEDVTFYLIIQRK
PLFYIVYTIIPCILISILAILVFYLPPDAGEKMSLSISALLAVTVFLLLLADKVPETSLS
VPIIIRYLMFIMILVAFSVILSVVVLNLHHRSPNTHTMPNWIRQIFIETLPPFLWIQRPV
TTPSPDSKPTIISRANDEYFIRKPAGDFVCPVDNARVAVQPERLFSEMKWHLNGLTQPVT
LPQDLKEAVEAIKYIAEQLESASEFDDLKKDWQYVAMVADRLFLYVFFVICSIGTFSIFL
DASHNVPPDNPFA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
Component 2
Name:Acetylcholine receptor subunit gamma
Synonyms:ACHG_TETCF | Acetylcholine receptor | CHRNG
Type:PROTEIN
Mol. Mass.:58151.68
Organism:Torpedo californica
Description:EBI_19662
Residue:506
Sequence:
MVLTLLLIICLALEVRSENEEGRLIEKLLGDYDKRIIPAKTLDHIIDVTLKLTLTNLISL
NEKEEALTTNVWIEIQWNDYRLSWNTSEYEGIDLVRIPSELLWLPDVVLENNVDGQFEVA
YYANVLVYNDGSMYWLPPAIYRSTCPIAVTYFPFDWQNCSLVFRSQTYNAHEVNLQLSAE
EGEAVEWIHIDPEDFTENGEWTIRHRPAKKNYNWQLTKDDTDFQEIIFFLIIQRKPLFYI
INIIAPCVLISSLVVLVYFLPAQAGGQKCTLSISVLLAQTIFLFLIAQKVPETSLNVPLI
GKYLIFVMFVSMLIVMNCVIVLNVSLRTPNTHSLSEKIKHLFLGFLPKYLGMQLEPSEET
PEKPQPRRRSSFGIMIKAEEYILKKPRSELMFEEQKDRHGLKRVNKMTSDIDIGTTVDLY
KDLANFAPEIKSCVEACNFIAKSTKEQNDSGSENENWVLIGKVIDKACFWIALLLFSIGT
LAIFLTGHFNQVPEFPFPGDPRKYVP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
Component 3
Name:Acetylcholine receptor subunit alpha
Synonyms:ACHA_TETCF | Acetylcholine receptor | Acetylcholine receptor protein alpha chain | CHRNA1
Type:PROTEIN
Mol. Mass.:52735.09
Organism:Torpedo californica
Description:ChEMBL_216981
Residue:461
Sequence:
MILCSYWHVGLVLLLFSCCGLVLGSEHETRLVANLLENYNKVIRPVEHHTHFVDITVGLQ
LIQLISVDEVNQIVETNVRLRQQWIDVRLRWNPADYGGIKKIRLPSDDVWLPDLVLYNNA
DGDFAIVHMTKLLLDYTGKIMWTPPAIFKSYCEIIVTHFPFDQQNCTMKLGIWTYDGTKV
SISPESDRPDLSTFMESGEWVMKDYRGWKHWVYYTCCPDTPYLDITYHFIMQRIPLYFVV
NVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGK
YMLFTMIFVISSIIITVVVINTHHRSPSTHTMPQWVRKIFIDTIPNVMFFSTMKRASKEK
QENKIFADDIDISDISGKQVTGEVIFQTPLIKNPDVKSAIEGVKYIAEHMKSDEESSNAA
EEWKYVAMVIDHILLCVFMLICIIGTVSVFAGRLIELSQEG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
Component 4
Name:Acetylcholine receptor subunit delta
Synonyms:ACHD_TETCF | Acetylcholine receptor | Acetylcholine receptor protein delta chain | chrnd
Type:PROTEIN
Mol. Mass.:59885.01
Organism:Torpedo californica
Description:ChEMBL_142744
Residue:522
Sequence:
MGNIHFVYLLISCLYYSGCSGVNEEERLINDLLIVNKYNKHVRPVKHNNEVVNIALSLTL
SNLISLKETDETLTSNVWMDHAWYDHRLTWNASEYSDISILRLPPELVWIPDIVLQNNND
GQYHVAYFCNVLVRPNGYVTWLPPAIFRSSCPINVLYFPFDWQNCSLKFTALNYDANEIT
MDLMTDTIDGKDYPIEWIIIDPEAFTENGEWEIIHKPAKKNIYPDKFPNGTNYQDVTFYL
IIRRKPLFYVINFITPCVLISFLASLAFYLPAESGEKMSTAISVLLAQAVFLLLTSQRLP
ETALAVPLIGKYLMFIMSLVTGVIVNCGIVLNFHFRTPSTHVLSTRVKQIFLEKLPRILH
MSRADESEQPDWQNDLKLRRSSSVGYISKAQEYFNIKSRSELMFEKQSERHGLVPRVTPR
IGFGNNNENIAASDQLHDEIKSGIDSTNYIVKQIKEKNAYDEEVGNWNLVGQTIDRLSMF
IITPVMVLGTIFIFVMGNFNHPPAKPFEGDPFDYSSDHPRCA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50023331
n/a
NameBDBM50023331
Synonyms:(+)-pyrido[3,4-b]homotropane | (+/-)-pyrido[3,4-b]homotropane | (-)-pyrido[3,4-b]homotropane | 4,13-Diaza-tricyclo[8.2.1.0*2,7*]trideca-2(7),3,5-triene | 4,13-Diaza-tricyclo[8.2.1.0*2,7*]trideca-2(7),3,5-triene(PHT) | CHEMBL149667
TypeSmall organic molecule
Emp. Form.C11H14N2
Mol. Mass.174.2423
SMILESC1CC2NC1CCc1ccncc21
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: