Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50024470 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_54896 |
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IC50 | >200000±n/a nM |
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Citation | Nair, MG; Dhawan, R; Ghazala, M; Kalman, TI; Ferone, R; Gaumont, Y; Kisliuk, RL Folate analogues. 30. Synthesis and biological evaluation of N10-propargyl-5,8-dideaza-5,6,7,8-tetrahydrofolic acid and related compounds. J Med Chem30:1256-61 (1987) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DYR_LACCA | dhfR | folA |
Type: | PROTEIN |
Mol. Mass.: | 18437.08 |
Organism: | Lactobacillus casei |
Description: | ChEMBL_1357878 |
Residue: | 163 |
Sequence: | MTAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTN
VVLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLA
GSFEGDTKMIPLNWDDFTKVSSRTVEDTNPALTHTYEVWQKKA
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BDBM50024470 |
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n/a |
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Name | BDBM50024470 |
Synonyms: | 4-[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-quinazolin-6-ylmethyl)-methyl-amino]-benzoic acid | CHEMBL22449 |
Type | Small organic molecule |
Emp. Form. | C17H20N4O3 |
Mol. Mass. | 328.3657 |
SMILES | CN(CC1CCc2nc(N)[nH]c(=O)c2C1)c1ccc(cc1)C(O)=O |
Structure |
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