| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50024472 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_54896 |
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| IC50 | >200000±n/a nM |
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| Citation |  Nair, MG; Dhawan, R; Ghazala, M; Kalman, TI; Ferone, R; Gaumont, Y; Kisliuk, RL Folate analogues. 30. Synthesis and biological evaluation of N10-propargyl-5,8-dideaza-5,6,7,8-tetrahydrofolic acid and related compounds. J Med Chem30:1256-61 (1987) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_LACCA | dhfR | folA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 18437.08 |
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| Organism: | Lactobacillus casei |
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| Description: | ChEMBL_1357878 |
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| Residue: | 163 |
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| Sequence: | MTAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTN
VVLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLA
GSFEGDTKMIPLNWDDFTKVSSRTVEDTNPALTHTYEVWQKKA
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|
|
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| BDBM50024472 |
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| n/a |
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| Name | BDBM50024472 |
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| Synonyms: | 4-[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-quinazolin-6-ylmethyl)-amino]-benzoic acid | CHEMBL441958 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H18N4O3 |
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| Mol. Mass. | 314.3391 |
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| SMILES | Nc1nc2CCC(CNc3ccc(cc3)C(O)=O)Cc2c(=O)[nH]1 |
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| Structure | 
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