Reaction Details |
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Target | Thymidylate synthase |
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Ligand | BDBM50023902 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_209806 (CHEMBL815672) |
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IC50 | 10000±n/a nM |
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Citation | Nair, MG; Dhawan, R; Ghazala, M; Kalman, TI; Ferone, R; Gaumont, Y; Kisliuk, RL Folate analogues. 30. Synthesis and biological evaluation of N10-propargyl-5,8-dideaza-5,6,7,8-tetrahydrofolic acid and related compounds. J Med Chem30:1256-61 (1987) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Thymidylate synthase |
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Name: | Thymidylate synthase |
Synonyms: | TS | TSase | TYSY_MOUSE | Tyms |
Type: | PROTEIN |
Mol. Mass.: | 34957.15 |
Organism: | Mus musculus |
Description: | ChEMBL_1340097 |
Residue: | 307 |
Sequence: | MLVVGSELQSDAQQLSAEAPRHGELQYLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYS
LRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSAR
QEGDLGPVYGFQWRHFGAEYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKD
LPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPG
DFVHTLGDAHIYLNHIEPLKIQLQREPRPFPKLKILRKVETIDDFKVEDFQIEGYNPHPT
IKMEMAV
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BDBM50023902 |
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n/a |
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Name | BDBM50023902 |
Synonyms: | 2-{4-[(2-Amino-4-oxo-1,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid (DDF) | 2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid | CHEMBL22973 | TCMDC-132046 |
Type | Small organic molecule |
Emp. Form. | C21H21N5O6 |
Mol. Mass. | 439.4213 |
SMILES | Nc1nc2ccc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cc2c(=O)[nH]1 |
Structure |
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