Reaction Details |
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Target | Neutrophil elastase |
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Ligand | BDBM50025846 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_218507 |
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Ki | 320000±n/a nM |
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Citation | Groutas, WC; Abrams, WR; Theodorakis, MC; Kasper, AM; Rude, SA; Badger, RC; Ocain, TD; Miller, KE; Moi, MK; Brubaker, MJ Amino acid derived latent isocyanates: irreversible inactivation of porcine pancreatic elastase and human leukocyte elastase. J Med Chem28:204-9 (1985) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Neutrophil elastase |
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Name: | Neutrophil elastase |
Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
Type: | Enzyme |
Mol. Mass.: | 28532.38 |
Organism: | Homo sapiens (Human) |
Description: | P08246 |
Residue: | 267 |
Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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BDBM50025846 |
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n/a |
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Name | BDBM50025846 |
Synonyms: | 2-[(Imidazole-1-carbonyl)-amino]-pentanoic acid methyl ester | CHEMBL306418 |
Type | Small organic molecule |
Emp. Form. | C10H15N3O3 |
Mol. Mass. | 225.2444 |
SMILES | CCC[C@H](NC(=O)n1ccnc1)C(=O)OC |
Structure |
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