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TargetNeutrophil elastase
LigandBDBM50025856
Substrate/Competitorn/a
Meas. Tech.ChEBML_63792
IC50 1620000±n/a nM
Citation Groutas, WCStanga, MABrubaker, MJHuang, TLMoi, MKCarroll, RT Substituted 2-pyrones, 2-pyridones, and other congeners of elasnin as potential agents for the treatment of chronic obstructive lung diseases. J Med Chem28:1106-9 (1985) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Neutrophil elastase
Name:Neutrophil elastase
Synonyms:Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:Enzyme
Mol. Mass.:28532.38
Organism:Homo sapiens (Human)
Description:P08246
Residue:267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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  Blast E-value cutoff:
BDBM50025856
n/a
NameBDBM50025856
Synonyms:6-(1-Butyl-heptyl)-4-hydroxy-pyran-2-one | CHEMBL12969
TypeSmall organic molecule
Emp. Form.C16H26O3
Mol. Mass.266.3758
SMILESCCCCCCC(CCCC)c1cc(O)cc(=O)o1
Structure
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