Reaction Details |
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Target | Neutrophil elastase |
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Ligand | BDBM50024652 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_63792 |
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IC50 | 26800±n/a nM |
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Citation | Groutas, WC; Stanga, MA; Brubaker, MJ; Huang, TL; Moi, MK; Carroll, RT Substituted 2-pyrones, 2-pyridones, and other congeners of elasnin as potential agents for the treatment of chronic obstructive lung diseases. J Med Chem28:1106-9 (1985) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Neutrophil elastase |
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Name: | Neutrophil elastase |
Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
Type: | Enzyme |
Mol. Mass.: | 28532.38 |
Organism: | Homo sapiens (Human) |
Description: | P08246 |
Residue: | 267 |
Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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BDBM50024652 |
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n/a |
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Name | BDBM50024652 |
Synonyms: | 3-Dodecanoyl-4-hydroxy-6-methyl-pyran-2-one | CHEMBL7839 |
Type | Small organic molecule |
Emp. Form. | C18H28O4 |
Mol. Mass. | 308.4125 |
SMILES | CCCCCCCCCCCC(=O)c1c(O)cc(C)oc1=O |
Structure |
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