Reaction Details |
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Target | Gamma-aminobutyric acid receptor subunit alpha-2 |
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Ligand | BDBM24183 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_68610 |
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IC50 | 22±n/a nM |
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Citation | Müller-Uri, C; Singer, EA; Fleischhacker, W Synthesis of alkyl-substituted arecoline derivatives as gamma-aminobutyric acid uptake inhibitors. J Med Chem29:125-32 (1986) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Gamma-aminobutyric acid receptor subunit alpha-2 |
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Name: | Gamma-aminobutyric acid receptor subunit alpha-2 |
Synonyms: | GABA A Alpha2Beta2Gamma2 | GABA A alpha2 | GABA A receptor alpha-2/beta-2/gamma-2 | GABA receptor alpha-2 subunit | GABA(A) receptor subunit alpha-2 | GBRA2_RAT | Gabra-2 | Gabra2 | Gamma-aminobutyric acid receptor subunit alpha-2 |
Type: | Enzyme |
Mol. Mass.: | 51195.57 |
Organism: | Rattus norvegicus (Rat) |
Description: | P23576 |
Residue: | 451 |
Sequence: | MRTKLSTCNVWFPLLVLLVWNPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPG
LGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNSMASK
IWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSC
PLKFGSYAYTTSEVTYIWTYNPSDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVM
TAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISA
RNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKGSV
MIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRM
SRIVFPVLFGTFNLVYWATYLNREPVLGVSP
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BDBM24183 |
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n/a |
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Name | BDBM24183 |
Synonyms: | 4-amino-n-[2,3-3H]butyric acid | 4-aminobutanoic acid | Aminalon | CHEMBL96 | GABA | Gamma-Aminobutyric acid | [3H]GABA | cid_119 |
Type | Radiolabeled ligand |
Emp. Form. | C4H9NO2 |
Mol. Mass. | 103.1198 |
SMILES | NCCCC(O)=O |
Structure |
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