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TargetDihydrofolate reductase
LigandBDBM50026389
Substrate/Competitorn/a
Meas. Tech.ChEBML_54600
Ki 0.004000±n/a nM
Citation Piper, JRMcCaleb, GSMontgomery, JASchmid, FASirotnak, FM Syntheses and evaluation as antifolates of MTX analogues derived from 2, omega-diaminoalkanoic acids. J Med Chem28:1016-25 (1985) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:DYR_MOUSE | Dhfr
Type:Enzyme
Mol. Mass.:21608.82
Organism:Mus musculus (Mouse)
Description:n/a
Residue:187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKF
EVYEKKD
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  Blast E-value cutoff:
BDBM50026389
n/a
NameBDBM50026389
Synonyms:2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-ureido-butyric acid | CHEMBL7684
TypeSmall organic molecule
Emp. Form.C20H24N10O4
Mol. Mass.468.4692
SMILESCN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)NC(CCNC(N)=O)C(O)=O
Structure
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