Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50026401 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_54600 |
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Ki | 3.24000±n/a nM |
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Citation | Piper, JR; McCaleb, GS; Montgomery, JA; Schmid, FA; Sirotnak, FM Syntheses and evaluation as antifolates of MTX analogues derived from 2, omega-diaminoalkanoic acids. J Med Chem28:1016-25 (1985) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DYR_MOUSE | Dhfr |
Type: | Enzyme |
Mol. Mass.: | 21608.82 |
Organism: | Mus musculus (Mouse) |
Description: | n/a |
Residue: | 187 |
Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKF
EVYEKKD
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BDBM50026401 |
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n/a |
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Name | BDBM50026401 |
Synonyms: | 2--[3-(2-Carboxy-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-ethylchloro) -n-nitraso]-ethyl ester | CHEMBL8210 |
Type | Small organic molecule |
Emp. Form. | C23H28ClN11O5 |
Mol. Mass. | 573.992 |
SMILES | CCOC(=O)C(CNC(=O)N(CCCl)N=O)NC(=O)c1ccc(cc1)N(C)Cc1cnc2nc(N)nc(N)c2n1 |
Structure |
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