Ki Summary

Reaction Details

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Target

DNA polymerase beta

Ligand

BDBM50027112

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_50773

IC50

15000±n/a nM

Citation

Wu, RS; Wolpert-DeFilippes, MK; Quinn, FR Quantitative structure--activity correlations of rifamycins as inhibitors of viral RNA-directed DNA polymerase and mammalian alpha and beta DNA polymerases. J Med Chem23:256-61 (1980) [PubMed]

More Info.:

Get all data from this article, Assay Method

DNA polymerase beta

Name:

DNA polymerase beta

Synonyms:

DPOLB_MOUSE | Polb

Type:

PROTEIN

Mol. Mass.:

38297.87

Organism:

Mus musculus

Description:

ChEMBL_50773

Residue:

335

Sequence:

MSKRKAPQETLNGGITDMLVELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAK
KLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVTGIGPSAARKFVDEGIK
TLEDLRKNEDKLNHHQRIGLKYFEDFEKRIPREEMLQMQDIVLNEIKKVDSEYIATVCGS
FRRGAESSGDMDVLLTHPNFTSESSKQPKLLHRVVEQLQKVHFITDTLSKGETKFMGVCQ
LPSEKDGKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRP
LGVTGVAGEPLPVDSEQDIFDYIQWRYREPKDRSE

BDBM50027112

n/a

Name

BDBM50027112

Synonyms:

2,15,17,29-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-N-Cyclopentadecyl-N'-methylene-hydrazine-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(28),2,4,9,19,21,25(29),26-octaen-13-yl acetate | CHEMBL441064

Type

Small organic molecule

Emp. Form.

C53H77N3O11

Mol. Mass.

932.192

SMILES

[#6]-[#8]-[#6]-1\[#6]=[#6]\[#8]C2([#6])[#8]-c3c(-[#6]2=O)c2cc(-[#6]-[#7]\[#7]=[#6]-4\[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-4)c(-[#7]-[#6](=O)-[#6](-[#6])=[#6]-[#6]=[#6]-[#6](-[#6])-[#6](-[#8])-[#6](-[#6])-[#6](-[#8])-[#6](-[#6])-[#6](-[#8]-[#6](-[#6])=O)-[#6]-1-[#6])c(-[#8])c2c(-[#8])c3-[#6] |w:40.42,42.44,t:3|

Structure