| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histamine H2 receptor |
|---|
| Ligand | BDBM31005 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_85066 |
|---|
| IC50 | 3800±n/a nM |
|---|
| Citation |  Watthey, JW; Gavin, T; Desai, M; Finn, BM; Rodebaugh, RK; Patt, SL Synthesis and biological properties of thiophene ring analogues of mianserin. J Med Chem26:1116-22 (1983) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histamine H2 receptor |
|---|
| Name: | Histamine H2 receptor |
|---|
| Synonyms: | Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_CAVPO | Histamine H2-Gs alpha S |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 40567.22 |
|---|
| Organism: | Cavia porcellus (domestic guinea pig) |
|---|
| Description: | For the H2 receptor-binding assays, guinea pig striatum was used. |
|---|
| Residue: | 359 |
|---|
| Sequence: | MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSL
AVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
TDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNE
VYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVM
GAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYH
QLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
|
|
|
|---|
| BDBM31005 |
|---|
| n/a |
|---|
| Name | BDBM31005 |
|---|
| Synonyms: | 2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine | MIANSERIN HYDROCHLORIDE | MLS000069681 | SMR000058472 | cid_68551 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H21ClN2 |
|---|
| Mol. Mass. | 300.826 |
|---|
| SMILES | Cl.CN1CCN2C(C1)c1ccccc1Cc1ccccc21 |
|---|
| Structure | 
|
|---|
Search and Browse
