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TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5
LigandBDBM83449
Substrate/Competitorn/a
Meas. Tech.ChEMBL_138645 (CHEMBL749274)
Kd 9100±n/a nM
Citation Kalir, A; Teomy, S; Amir, A; Fuchs, P; Lee, SA; Holsztynska, EJ; Rocki, W; Domino, EF N-allyl analogues of phencyclidine: chemical synthesis and pharmacological properties. J Med Chem27:1267-71 (1984) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
Name:Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
Synonyms:Muscarinic acetylcholine receptor
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 138646
Components:This complex has 5 components.
Component 1
Name:Muscarinic acetylcholine receptor M2
Synonyms:ACM2_MOUSE | Chrm-2 | Chrm2 | Muscarinic acetylcholine receptor
Type:PROTEIN
Mol. Mass.:51515.43
Organism:Mus musculus
Description:ChEMBL_139897
Residue:466
Sequence:
MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRI
VKPNNNNMPGGDGGLEHNKIQNGKAPRDGGTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSKDDNSRQTCIKIVTKTQKGDACTPTSTTVELVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
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Component 2
Name:Muscarinic acetylcholine receptor M5
Synonyms:ACM5_MOUSE | Chrm5 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M5
Type:PROTEIN
Mol. Mass.:60282.66
Organism:Mus musculus
Description:ChEMBL_104873
Residue:532
Sequence:
MEGESYHNETTVNGTPVNHQALERHGLWEVITIAAVTAVVSLMTIVGNVLVMISFKVNSQ
LKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWVLGSLACDLWLALDYVASNASVMN
LLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLVSFILWAPAILCWQYLVGKRTVPP
DECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVAEVK
KRKPAHRTLLRSFFSCPRPSLAQRVRNQASWSSSRRSTSTTGKPTQATDLSADWEKAEQV
TNCSSCPSSEDEAKATTDPVFQVVCKNEAKESPGKEFNTQETKETFVSPRTENNDYDTPK
YFLSPGAAHRLKSQKCVAYKFRLVVKADGTQETNNGCRKVKIMPCSFPVSKDPSTKGLDP
HLSHQMTKRKRMVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLG
YWLCYVNSTINPICYALCNRTFRKTFKLLLLCRWKKKKVEEKLYWQGNSKLP
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Component 3
Name:Muscarinic acetylcholine receptor M4
Synonyms:ACM4_MOUSE | Cholinergic, muscarinic M4 | Chrm-4 | Chrm4 | Mm4 mAChR | Muscarinic acetylcholine receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:53004.88
Organism:MOUSE
Description:Cholinergic, muscarinic M4 CHRM4 MOUSE::P32211
Residue:479
Sequence:
MANFTPVNGSSANQSVRLVTTAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNR
QLQTVNNYFLFSLACADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVM
NLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVP
DNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKT
LAFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSA
TQNTKERPPTELSTTEAATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGSECVTAIEIV
PATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMV
LVNTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
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Component 4
Name:Muscarinic acetylcholine receptor M3
Synonyms:ACM3_MOUSE | Chrm-3 | Chrm3 | Mm3 mAChR | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M3
Type:PROTEIN
Mol. Mass.:66232.94
Organism:Mus musculus
Description:ChEMBL_138834
Residue:589
Sequence:
MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVSQLDSYNISQTSGNFSSNDTSSDPLG
GHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVIS
MNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRT
TKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFY
MPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGTK
RSSRRKYGGCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSET
RAIYSIVLKLPGHSTILNSTKLPSSDNLQVPDKDLGTMDVERNAHKLQAQKSMDDRDNCQ
KDFSKLPIQLESAVDTAKTSDTNSSVDKTTAALPLSFKEATLAKRFALKTRSQITKRKRM
SLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNP
VCYALCNKTFRTTFKMLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
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Component 5
Name:Muscarinic acetylcholine receptor M1
Synonyms:ACM1_MOUSE | Cholinergic receptor, muscarinic 1, CNS | Cholinergic, muscarinic | Chrm-1 | Chrm1 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M1
Type:Enzyme Catalytic Domain
Mol. Mass.:51400.50
Organism:Mus musculus
Description:Cholinergic, muscarinic 0 0::Q52KQ0
Residue:460
Sequence:
MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDPEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
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BDBM83449
n/a
NameBDBM83449
Synonyms:1-(1-phenylcyclohexyl)piperidine;hydrochloride | MLS002320664 | PCP | PCP hydrochloride | PHENCYCLIDINE | Phencyclidine hydrochloride | SMR001338811 | cid_9795678
TypeSmall organic molecule
Emp. Form.C17H25N
Mol. Mass.243.3871
SMILESC1CCN(CC1)C1(CCCCC1)c1ccccc1
Structure
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