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TargetFolylpolyglutamate synthase, mitochondrial
LigandBDBM50023710
Substrate/Competitorn/a
Meas. Tech.ChEBML_68664
Ki 59000±n/a nM
Citation Rosowsky, AForsch, RAFreisheim, JHMoran, RGWick, M Methotrexate analogues. 19. Replacement of the glutamate side chain in classical antifolates by L-homocysteic acid and L-cysteic acid: effect on enzyme inhibition and antitumor activity. J Med Chem27:600-4 (1984) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Folylpolyglutamate synthase, mitochondrial
Name:Folylpolyglutamate synthase, mitochondrial
Synonyms:FOLC_HUMAN | FPGS | Folylpoly-gamma-glutamate synthetase | Folylpolyglutamate synthase, mitochondrial | Tetrahydrofolate synthase | Tetrahydrofolylpolyglutamate synthase
Type:PROTEIN
Mol. Mass.:64621.95
Organism:Homo sapiens (Human)
Description:ChEMBL_68676
Residue:587
Sequence:
MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAG
YLEQVKRQRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVTGTKGKGSTCAFTECILRS
YGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHRLEETKDGSCVSMPPYFRF
LTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIA
WQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCPMLEALEEGGPPLTLGLEGE
HQRSNAALALQLAHCWLQRQDRHGAGEPKASRPGLLWQLPLAPVFQPTSHMRLGLRNTEW
PGRTQVLRRGPLTWYLDGAHTASSAQACVRWFRQALQGRERPSGGPEVRVLLFNATGDRD
PAALLKLLQPCQFDYAVFCPNLTEVSSTGNADQQNFTVTLDQVLLRCLEHQQHWNHLDEE
QASPDLWSAPSPEPGGSASLLLAPHPPHTCSASSLVFSCISHALQWISQGRDPIFQPPSP
PKGLLTHPVAHSGASILREAAAIHVLVTGSLHLVGGVLKLLEPALSQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50023710
n/a
NameBDBM50023710
Synonyms:2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-benzoylamino}-4-sulfo-butyric acid | CHEMBL281936
TypeSmall organic molecule
Emp. Form.C18H20N8O6S
Mol. Mass.476.466
SMILESNc1nc(N)c2nc(CNc3ccc(cc3)C(=O)NC(CCS(O)(=O)=O)C(O)=O)cnc2n1
Structure
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