| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50026314 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_54543 |
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| Ki | 0.066000±n/a nM |
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| Citation |  Kuyper, LF; Roth, B; Baccanari, DP; Ferone, R; Beddell, CR; Champness, JN; Stammers, DK; Dann, JG; Norrington, FE; Baker, DJ; Goodford, PJ Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogues. J Med Chem25:1120-2 (1983) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | Dihydrofolate reductase (F31V) | dfrA17 |
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| Type: | n/a |
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| Mol. Mass.: | 17532.46 |
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| Organism: | Escherichia coli |
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| Description: | n/a |
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| Residue: | 157 |
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| Sequence: | MKISLISAVSESGVIGSGPDIPWSVKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYA
VVSKNGISSSNENVLVFPSIENALKELSKVTDHVYVSGGGQIYNSLIEKADIIHLSTVHV
EVEGDIKFPIMPENFNLVFEQFFMSNINYTYQIWKKG
|
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|
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| BDBM50026314 |
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| n/a |
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| Name | BDBM50026314 |
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| Synonyms: | 5-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimethoxy-phenoxy]-pentanoic acid | CHEMBL13673 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H24N4O5 |
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| Mol. Mass. | 376.407 |
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| SMILES | COc1cc(Cc2cnc(N)nc2N)cc(OCCCCC(O)=O)c1OC |
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| Structure | 
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