| Reaction Details |
|---|
 | Report a problem with these data |
| Target | DNA topoisomerase 3 |
|---|
| Ligand | BDBM50028342 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_54508 |
|---|
| Ki | 930.0±n/a nM |
|---|
| Citation |  Wright, GE; Brown, NC Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils. J Med Chem23:34-8 (1980) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| DNA topoisomerase 3 |
|---|
| Name: | DNA topoisomerase 3 |
|---|
| Synonyms: | DNA topoisomerase III | TOP3_BACSU | topB |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 81515.22 |
|---|
| Organism: | Bacillus subtilis |
|---|
| Description: | ChEMBL_54525 |
|---|
| Residue: | 727 |
|---|
| Sequence: | MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDQYIVTWALGHLVTLADPEGYGKEFQS
WRLEDLPIIPEPLKLVVIKKTGKQFNAVKSQLTRKDVNQIVIATDAGREGELVARWIIEK
ANVRKPIKRLWISSVTDKAIKEGFQKLRSGKEYENLYHSAVARAEADWIVGINATRALTT
KFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGIRAAVDGMTLTWQDKKSKQTRTFN
QDVTSRLLKNLQGKQAVVAELKKTAKKSFAPALYDLTELQRDAHKRFGFSAKETLSVLQK
LYEQHKLVTYPRTDSRFLSSDIVPTLKDRLEGMEVKPYAQYVSQIKKRGIKSHKGYVNDA
KVSDHHAIIPTEEPLVLSSLSDKERKLYDLIAKRFLAVLMPAFEYEETKVIAEIGGETFT
AKGKTVQSQGWKAVYDMAEEDDEQEDDRDQTLPALQKGDTLAVRTLTETSGQTKPPARFN
EGTLLSAMENPSAFMQGEEKGLVKTLGETGGLGTVATRADIIEKLFNSFLIEKKGQDIFI
TSKGKQLLQLVPEDLKSPALTAEWEQKLSAIAAGKLKSAVFIKDMKAYAHQTVKEIKNSS
QTFRHDNITGTACPECGKMMLKVNGKRGTMLVCQDRECGSRKTIARKTNARCPNCHKRME
LRGQGEGQTFACVCGHREKLSVFEKRKNKDKARATKRDVSSYMKKQNKDEPINNALAEQL
KKLGLDK
|
|
|
|---|
| BDBM50028342 |
|---|
| n/a |
|---|
| Name | BDBM50028342 |
|---|
| Synonyms: | 6-(3,4-Dichloro-phenylamino)-1H-pyrimidine-2,4-dione | CHEMBL52034 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H7Cl2N3O2 |
|---|
| Mol. Mass. | 272.087 |
|---|
| SMILES | Clc1ccc(Nc2cc(=O)[nH]c(=O)[nH]2)cc1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
