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TargetThymidylate Synthase (TS)
LigandBDBM50028377
Substrate/Competitorn/a
Meas. Tech.ChEBML_217700
Ki 3000±n/a nM
Citation Barr PJNolan PASanti DVRobins MJ Inhibition of thymidylate synthetase by 5-alkynyl-2'-deoxyuridylates. J Med Chem 24:1385-8 (1982) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Thymidylate Synthase (TS)
Name:Thymidylate synthase
Synonyms:TSase | Thymidylate synthase
Type:Enzyme
Mol. Mass.:36576.54
Organism:Lactobacillus casei
Description:n/a
Residue:316
Sequence:
MLEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSE
LLWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHE
EMAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAWHTSKGDTIDQLGDVIEQIKTHPYSRRL
IVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFNIASYALLTHLV
AHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDFDMKDIK
LLNYDPYPAIKAPVAV
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  Blast E-value cutoff:
BDBM50028377
n/a
NameBDBM50028377
Synonyms:CHEMBL29053 | CHEMBL3143869 | Phosphoric acid mono-{3-hydroxy-5-[5-(3-hydroxy-prop-1-ynyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-2-ylmethyl} ester
TypeSmall organic molecule
Emp. Form.C12H15N2O9P
Mol. Mass.362.2293
SMILESOCC#Cc1cn([C@H]2C[C@H](O)[C@@H](COP(O)(O)=O)O2)c(=O)[nH]c1=O |r|
Structure
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