| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Phenylalanine-4-hydroxylase |
|---|
| Ligand | BDBM50028427 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_154856 |
|---|
| Ki | 125000±n/a nM |
|---|
| Citation |  Henrie, RN; Lazarus, RA; Benkovic, SJ Preparation of 2-amino-4(3H)-oxopyrimido[5,4-b] [1,4]thiazines (5-thiapterins) and their evaluation as cofactors for phenylalanine hydroxylase. J Med Chem26:559-63 (1983) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Phenylalanine-4-hydroxylase |
|---|
| Name: | Phenylalanine-4-hydroxylase |
|---|
| Synonyms: | PH4H_RAT | Pah | Phe-4-monooxygenase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 51817.61 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_154856 |
|---|
| Residue: | 453 |
|---|
| Sequence: | MAAVVLENGVLSRKLSDFGQETSYIEDNSNQNGAISLIFSLKEEVGALAKVLRLFEENDI
NLTHIESRPSRLNKDEYEFFTYLDKRTKPVLGSIIKSLRNDIGATVHELSRDKEKNTVPW
FPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYT
EEEKQTWGTVFRTLKALYKTHACYEHNHIFPLLEKYCGFREDNIPQLEDVSQFLQTCTGF
RLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFA
QFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKEGDSIKAYGAGLLSSFGELQYCLSD
KPKLLPLELEKTACQEYSVTEFQPLYYVAESFSDAKEKVRTFAATIPRPFSVRYDPYTQR
VEVLDNTQQLKILADSINSEVGILCNALQKIKS
|
|
|
|---|
| BDBM50028427 |
|---|
| n/a |
|---|
| Name | BDBM50028427 |
|---|
| Synonyms: | 2-Amino-6-methyl-5-oxo-5,6,7,8-tetrahydro-3H-5lambda*4*-pyrimido[5,4-b][1,4]thiazin-4-one | CHEMBL345752 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C7H8N4O2S |
|---|
| Mol. Mass. | 212.229 |
|---|
| SMILES | CC1=CNc2nc(N)[nH]c(=O)c2S1=O |t:1| |
|---|
| Structure | 
|
|---|
Search and Browse
