Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetSqualene synthetase
LigandBDBM50029163
Substrate/Competitorn/a
Meas. Tech.ChEMBL_202111
IC50 3±n/a nM
Citation Brown GRButlin RJChapman SEakin MAFoubister AJFreeman SGriffiths DHarrison PJJohnson MCMallion KB Phenoxypropylamines: a new series of squalene synthase inhibitors. J Med Chem 38:4157-60 (1995) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Squalene synthetase
Name:Squalene synthetase
Synonyms:FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | SQS | SS
Type:PROTEIN
Mol. Mass.:48109.41
Organism:Rattus norvegicus
Description:ChEMBL_1336736
Residue:416
Sequence:
MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDRNSLSNSLKTCYKYLDQTSRSFAAVIQA
LDGDIRHAVCVFYLILRAMDTVEDDMAISVEKKIPLLRNFHTFLYEPEWRFTESKEKHRV
VLEDFPTISLEFRNLAEKYQTVIADICHRMGCGMAEFLNKDVTSKQDWDKYCHYVAGLVG
IGLSRLFSASEFEDPIVGEDTECANSMGLFLQKTNIIRDYLEDQQEGRQFWPQEVWGKYV
KKLEDFVKPENVDVAVKCLNELITNALQHIPDVITYLSRLRNQSVFNFCAIPQVMAIATL
AACYNNHQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIYQYIEEIYHRVPNSDPSASKAK
QLISNIRTQSLPNCQLISRSHYSPIYLSFIMLLAALSWQYLSTLSQVTEDYVQREH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50029163
n/a
NameBDBM50029163
Synonyms:CHEMBL340992 | Propionic acid 4-(3-isopropylamino-propoxy)-phenyl ester
TypeSmall organic molecule
Emp. Form.C15H23NO3
Mol. Mass.265.348
SMILESCCC(=O)Oc1ccc(OCCCNC(C)C)cc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: