| Reaction Details |
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 | Report a problem with these data |
| Target | Squalene synthase |
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| Ligand | BDBM50029176 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_202111 (CHEMBL808969) |
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| IC50 | 900±n/a nM |
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| Citation |  Brown, GR; Butlin, RJ; Chapman, S; Eakin, MA; Foubister, AJ; Freeman, S; Griffiths, D; Harrison, PJ; Johnson, MC; Mallion, KB Phenoxypropylamines: a new series of squalene synthase inhibitors. J Med Chem38:4157-60 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Squalene synthase |
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| Name: | Squalene synthase |
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| Synonyms: | FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48109.41 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1336736 |
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| Residue: | 416 |
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| Sequence: | MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDRNSLSNSLKTCYKYLDQTSRSFAAVIQA
LDGDIRHAVCVFYLILRAMDTVEDDMAISVEKKIPLLRNFHTFLYEPEWRFTESKEKHRV
VLEDFPTISLEFRNLAEKYQTVIADICHRMGCGMAEFLNKDVTSKQDWDKYCHYVAGLVG
IGLSRLFSASEFEDPIVGEDTECANSMGLFLQKTNIIRDYLEDQQEGRQFWPQEVWGKYV
KKLEDFVKPENVDVAVKCLNELITNALQHIPDVITYLSRLRNQSVFNFCAIPQVMAIATL
AACYNNHQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIYQYIEEIYHRVPNSDPSASKAK
QLISNIRTQSLPNCQLISRSHYSPIYLSFIMLLAALSWQYLSTLSQVTEDYVQREH
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| BDBM50029176 |
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| n/a |
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| Name | BDBM50029176 |
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| Synonyms: | CHEMBL334964 | N-[3-Benzyl-4-(2-hydroxy-3-isopropylamino-propoxy)-phenyl]-propionamide |
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| Type | Small organic molecule |
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| Emp. Form. | C22H30N2O3 |
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| Mol. Mass. | 370.4852 |
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| SMILES | CCC(=O)Nc1ccc(OCC(O)CNC(C)C)c(Cc2ccccc2)c1 |
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| Structure | 
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