Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Peptidyl-prolyl cis-trans isomerase FKBP1B | ||
Ligand | BDBM50029194 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_154486 (CHEMBL765263) | ||
Ki | 33±n/a nM | ||
Citation | Hu, MK; Badger, A; Rich, DH Cyclosporin analogs modified in the 3,7,8-positions: substituent effects on peptidylprolyl isomerase inhibition and immunosuppressive activity are nonadditive. J Med Chem38:4164-70 (1995) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
Peptidyl-prolyl cis-trans isomerase FKBP1B | |||
Name: | Peptidyl-prolyl cis-trans isomerase FKBP1B | ||
Synonyms: | 12.6 kDa FKBP | FK506-binding protein 1B | FKB1B_HUMAN | FKBP-12.6 | FKBP-1B | FKBP12.6 | FKBP1B | FKBP1L | FKBP9 | Immunophilin FKBP12.6 | OTK4 | PPIase FKBP1B | Peptidyl-prolyl cis-trans isomerase FKBP1B | Rotamase | h-FKBP-12 | mTOR/FKBP12A/FKBP12B | ||
Type: | PROTEIN | ||
Mol. Mass.: | 11785.40 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1458980 | ||
Residue: | 108 | ||
Sequence: |
| ||
BDBM50029194 | |||
n/a | |||
Name | BDBM50029194 | ||
Synonyms: | 15-Benzyl-30-ethyl-33-(1-hydroxy-2-methyl-hex-4-enyl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,19,25,28-octamethyl-1,4,7,10,13,16,19,22,25,28,31undecaaza-cyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone | CHEMBL2370711 | ||
Type | Small organic molecule | ||
Emp. Form. | C68H115N11O12 | ||
Mol. Mass. | 1278.7072 | ||
SMILES | [H][C@]1(C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](CC)NC(=O)[C@]([H])([C@H](O)C(C)C\C=C\C)N(C)C1=O)C(C)C | ||
Structure |