| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50029351 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_65814 (CHEMBL679716) |
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| IC50 | 21±n/a nM |
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| Citation |  Fukami, T; Nagase, T; Fujita, K; Hayama, T; Niiyama, K; Mase, T; Nakajima, S; Fukuroda, T; Saeki, T; Nishikibe, M Structure-activity relationships of cyclic pentapeptide endothelin A receptor antagonists. J Med Chem38:4309-24 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA | EDNRA_PIG | Endothelin receptor ET-A |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48707.29 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_65803 |
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| Residue: | 427 |
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| Sequence: | METFCFRVSFWVALLGCVISDNPESHSTNLSTHVDDFTTFRGTEFSLVVTTHRPTNLALP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFENHDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEEHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHEQNNHNTERS
SHKDSIN
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| BDBM50029351 |
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| n/a |
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| Name | BDBM50029351 |
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| Synonyms: | CHEMBL342615 | [(5R,8S,11R,14S,16aR)-8-(1H-Indol-3-ylmethyl)-11-isobutyl-14-isopropyl-4,7,10,13,16-pentaoxo-hexadecahydro-3a,6,9,12,15-pentaaza-cyclopentacyclopentadecen-5-yl]-methanesulfonic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C30H42N6O8S |
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| Mol. Mass. | 646.755 |
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| SMILES | CC(C)C[C@H]1NC(=O)[C@@H](NC(=O)[C@H]2CCCN2C(=O)[C@H](CS(O)(=O)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C |
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| Structure | 
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