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TargetEndothelin receptor ET-A
LigandBDBM50029351
Substrate/Competitorn/a
Meas. Tech.ChEMBL_65814
IC50 21±n/a nM
Citation Fukami TNagase TFujita KHayama TNiiyama KMase TNakajima SFukuroda TSaeki TNishikibe M Structure-activity relationships of cyclic pentapeptide endothelin A receptor antagonists. J Med Chem 38:4309-24 (1995) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Endothelin receptor ET-A
Name:Endothelin receptor ET-A
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:48707.29
Organism:Sus scrofa
Description:ChEMBL_65803
Residue:427
Sequence:
METFCFRVSFWVALLGCVISDNPESHSTNLSTHVDDFTTFRGTEFSLVVTTHRPTNLALP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFENHDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEEHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHEQNNHNTERS
SHKDSIN
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  Blast E-value cutoff:
BDBM50029351
n/a
NameBDBM50029351
Synonyms:CHEMBL342615 | [(5R,8S,11R,14S,16aR)-8-(1H-Indol-3-ylmethyl)-11-isobutyl-14-isopropyl-4,7,10,13,16-pentaoxo-hexadecahydro-3a,6,9,12,15-pentaaza-cyclopentacyclopentadecen-5-yl]-methanesulfonic acid
TypeSmall organic molecule
Emp. Form.C30H42N6O8S
Mol. Mass.646.755
SMILESCC(C)C[C@H]1NC(=O)[C@@H](NC(=O)[C@H]2CCCN2C(=O)[C@H](CS(O)(=O)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C
Structure
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