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TargetHuman immunodeficiency virus type 1 reverse transcriptase
LigandBDBM50029662
Substrate/Competitorn/a
Meas. Tech.ChEMBL_195839
IC50 15±n/a nM
Citation Dollé VFan ENguyen CHAubertin AMKirn AAndreola MLJamieson GTarrago-Litvak LBisagni E A new series of pyridinone derivatives as potent non-nucleoside human immunodeficiency virus type 1 specific reverse transcriptase inhibitors. J Med Chem 38:4679-86 (1995) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Human immunodeficiency virus type 1 reverse transcriptase
Name:Human immunodeficiency virus type 1 reverse transcriptase
Synonyms:Reverse transcriptase/RNaseH
Type:PROTEIN
Mol. Mass.:65229.15
Organism:Human immunodeficiency virus 1
Description:ChEMBL_1473730
Residue:566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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  Blast E-value cutoff:
BDBM50029662
n/a
NameBDBM50029662
Synonyms:3-Amino-4-(3,5-dimethyl-phenylsulfanyl)-5-ethyl-6-methyl-1H-pyridin-2-one | CHEMBL336237
TypeSmall organic molecule
Emp. Form.C16H20N2OS
Mol. Mass.288.408
SMILESCCc1c(C)[nH]c(=O)c(N)c1Sc1cc(C)cc(C)c1
Structure
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