| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase/RNaseH |
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| Ligand | BDBM50029662 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_195839 (CHEMBL799138) |
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| IC50 | 15±n/a nM |
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| Citation |  Dollé, V; Fan, E; Nguyen, CH; Aubertin, AM; Kirn, A; Andreola, ML; Jamieson, G; Tarrago-Litvak, L; Bisagni, E A new series of pyridinone derivatives as potent non-nucleoside human immunodeficiency virus type 1 specific reverse transcriptase inhibitors. J Med Chem38:4679-86 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Reverse transcriptase/RNaseH |
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| Name: | Reverse transcriptase/RNaseH |
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| Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
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| Type: | PROTEIN |
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| Mol. Mass.: | 65229.15 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_1473730 |
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| Residue: | 566 |
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| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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| BDBM50029662 |
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| n/a |
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| Name | BDBM50029662 |
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| Synonyms: | 3-Amino-4-(3,5-dimethyl-phenylsulfanyl)-5-ethyl-6-methyl-1H-pyridin-2-one | CHEMBL336237 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H20N2OS |
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| Mol. Mass. | 288.408 |
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| SMILES | CCc1c(C)[nH]c(=O)c(N)c1Sc1cc(C)cc(C)c1 |
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| Structure | 
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