Reaction Details |
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Target | Neutrophil elastase |
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Ligand | BDBM50029711 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_64004 (CHEMBL672345) |
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Ki | 0.058±n/a nM |
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Citation | Hlasta, DJ; Ackerman, JH; Court, JJ; Farrell, RP; Johnson, JA; Kofron, JL; Robinson, DT; Talomie, TG; Dunlap, RP; Franke, CA A novel class of cyclic beta-dicarbonyl leaving groups and their use in the design of benzisothiazolone human leukocyte elastase inhibitors. J Med Chem38:4687-92 (1995) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Neutrophil elastase |
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Name: | Neutrophil elastase |
Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
Type: | Enzyme |
Mol. Mass.: | 28532.38 |
Organism: | Homo sapiens (Human) |
Description: | P08246 |
Residue: | 267 |
Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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BDBM50029711 |
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n/a |
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Name | BDBM50029711 |
Synonyms: | 3-Bromo-2-(4-isopropyl-6-methoxy-1,1,3-trioxo-1,3-dihydro-1lambda*6*-benzo[d]isothiazol-2-ylmethoxy)-pyrido[1,2-a]pyrimidin-4-one | CHEMBL142579 |
Type | Small organic molecule |
Emp. Form. | C20H18BrN3O6S |
Mol. Mass. | 508.342 |
SMILES | COc1cc2c(C(=O)N(COc3nc4ccccn4c(=O)c3Br)S2(=O)=O)c(c1)C(C)C |
Structure |
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