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TargetLeukocyte elastase
LigandBDBM50029718
Substrate/Competitorn/a
Meas. Tech.ChEMBL_64004
Ki 0.09±n/a nM
Citation Hlasta DJAckerman JHCourt JJFarrell RPJohnson JAKofron JLRobinson DTTalomie TGDunlap RPFranke CA A novel class of cyclic beta-dicarbonyl leaving groups and their use in the design of benzisothiazolone human leukocyte elastase inhibitors. J Med Chem 38:4687-92 (1995) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Leukocyte elastase
Name:Leukocyte elastase
Synonyms:Bone marrow serine protease | Chymotrypsin | Coagulation factor X | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:Enzyme
Mol. Mass.:28532.38
Organism:Homo sapiens (Human)
Description:P08246
Residue:267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50029718
n/a
NameBDBM50029718
Synonyms:4-Isopropyl-6-methoxy-1,1-dioxo-2-(2-oxo-2H-chromen-4-yloxymethyl)-1,2-dihydro-1lambda*6*-benzo[d]isothiazol-3-one | CHEMBL142555
TypeSmall organic molecule
Emp. Form.C21H19NO7S
Mol. Mass.429.443
SMILESCOc1cc2c(C(=O)N(COc3cc(=O)oc4ccccc34)S2(=O)=O)c(c1)C(C)C
Structure
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