Ki Summary

Reaction Details

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Target

Melanocyte-stimulating hormone receptor

Ligand

BDBM50454019

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_105838 (CHEMBL716497)

IC50

2±n/a nM

Citation

Haskell-Luevano, C; Boteju, LW; Miwa, H; Dickinson, C; Gantz, I; Yamada, T; Hadley, ME; Hruby, VJ Topographical modification of melanotropin peptide analogues with beta-methyltryptophan isomers at position 9 leads to differential potencies and prolonged biological activities. J Med Chem38:4720-9 (1995) [PubMed]

More Info.:

Get all data from this article, Assay Method

Melanocyte-stimulating hormone receptor

Name:

Melanocyte-stimulating hormone receptor

Synonyms:

Type:

Enzyme

Mol. Mass.:

34717.23

Organism:

Homo sapiens (Human)

Description:

Q01726

Residue:

317

Sequence:

MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVV
ATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVI
DVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFI
AYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGA
VTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAF
HSQELRRTLKEVLTCSW

BDBM50454019

n/a

Name

BDBM50454019

Synonyms:

CHEMBL2370906

Type

Small organic molecule

Emp. Form.

C51H73N15O10

Mol. Mass.

1056.2198

SMILES

CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]([C@H](C)c1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(N)=O |wU:12.11,30.30,67.70,4.3,wD:52.53,20.19,41.42,53.55,(-5.23,-3.6,;-3.9,-2.83,;-2.56,-3.6,;-1.23,-2.83,;.1,-3.6,;.1,-5.14,;-1.23,-5.91,;-2.56,-5.14,;-1.23,-7.45,;1.44,-2.83,;1.44,-1.29,;2.77,-3.6,;4.1,-2.83,;4.1,-1.29,;5.44,-.52,;6.77,-1.29,;5.44,1.02,;5.44,-3.6,;5.44,-5.14,;6.77,-2.83,;8.1,-3.6,;8.1,-5.14,;9.44,-5.91,;9.6,-7.44,;11.11,-7.76,;11.88,-6.42,;10.85,-5.28,;9.44,-2.83,;9.44,-1.29,;10.77,-3.6,;12.11,-2.83,;12.11,-1.29,;13.44,-.52,;14.77,-1.29,;16.11,-.52,;16.11,1.02,;14.77,1.79,;13.44,1.02,;13.44,-3.6,;13.44,-5.14,;14.77,-2.83,;16.11,-3.6,;16.11,-5.14,;14.77,-5.91,;14.77,-7.45,;13.44,-8.22,;13.44,-9.76,;12.11,-10.53,;14.77,-10.53,;17.44,-2.83,;17.44,-1.29,;18.77,-3.6,;20.11,-2.83,;20.11,-1.29,;18.77,-.52,;21.44,-.52,;22.85,-1.14,;23.88,0,;23.11,1.34,;23.58,2.8,;22.55,3.94,;21.05,3.62,;20.57,2.16,;21.6,1.02,;21.44,-3.6,;21.44,-5.14,;22.78,-2.83,;24.11,-3.6,;25.44,-2.83,;26.78,-3.6,;28.11,-2.83,;29.44,-3.6,;30.78,-2.83,;24.11,-5.14,;22.78,-5.91,;25.44,-5.91,)|

Structure