| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Substance-P receptor |
|---|
| Ligand | BDBM50030331 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_143031 (CHEMBL751903) |
|---|
| Ki | >10000±n/a nM |
|---|
| Citation |  Desai, MC; Vincent, LA; Rizzi, JP Importance of parallel vectors and"hydrophobic collapse" of the aligned aromatic rings: discovery of a potent substance P antagonist. J Med Chem37:4263-6 (1995) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Substance-P receptor |
|---|
| Name: | Substance-P receptor |
|---|
| Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 46254.43 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P25103 |
|---|
| Residue: | 407 |
|---|
| Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
|
|
|
|---|
| BDBM50030331 |
|---|
| n/a |
|---|
| Name | BDBM50030331 |
|---|
| Synonyms: | (2S,5R,6S)-2-(2-Methoxy-phenyl)-6-phenyl-1,7-diaza-spiro[4.5]decane | CHEMBL333308 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H26N2O |
|---|
| Mol. Mass. | 322.4439 |
|---|
| SMILES | COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)N1 |
|---|
| Structure | 
|
|---|
Search and Browse
