| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase/RNaseH |
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| Ligand | BDBM50030549 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_195358 (CHEMBL802598) |
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| IC50 | 14700±n/a nM |
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| Citation |  Maruenda, H; Johnson, F Design and synthesis of novel inhibitors of HIV-1 reverse transcriptase. J Med Chem38:2145-51 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase/RNaseH |
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| Name: | Reverse transcriptase/RNaseH |
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| Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
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| Type: | PROTEIN |
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| Mol. Mass.: | 65229.15 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_1473730 |
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| Residue: | 566 |
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| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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| BDBM50030549 |
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| n/a |
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| Name | BDBM50030549 |
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| Synonyms: | Acetic acid 2-(10-methyl-1,3-dioxo-2,3,10,11-tetrahydro-1H-5-thia-2,4,10-triaza-dibenzo[a,d]cyclohepten-4-ylmethoxy)-ethyl ester | CHEMBL67095 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H19N3O5S |
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| Mol. Mass. | 377.415 |
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| SMILES | CN1Cc2c(Sc3ccccc13)n(COCCOC(C)=O)c(=O)[nH]c2=O |
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| Structure | 
|
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