Reaction Details |
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Target | Type-1 angiotensin II receptor |
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Ligand | BDBM50030698 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_36952 (CHEMBL648855) |
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IC50 | 0.140000±n/a nM |
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Citation | Chang, LL; Ashton, WT; Flanagan, KL; Chen, TB; O'Malley, SS; Zingaro, GJ; Kivlighn, SD; Siegl, PK; Lotti, VJ; Chang, RS Potent and orally active angiotensin II receptor antagonists with equal affinity for human AT1 and AT2 subtypes. J Med Chem38:3741-58 (1995) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Type-1 angiotensin II receptor |
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Name: | Type-1 angiotensin II receptor |
Synonyms: | AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 41009.15 |
Organism: | RABBIT |
Description: | ANGIOTENSIN AT1 AGTR1 RABBIT::P34976 |
Residue: | 359 |
Sequence: | MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
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BDBM50030698 |
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n/a |
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Name | BDBM50030698 |
Synonyms: | CHEMBL435811 | N-{3-[3-Butyl-4-(3-fluoro-2'-(N-t-butyloxycarbonyl)-Sulfanamido-biphenyl-4-ylmethyl)-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-4-chloro-phenyl}-3-methoxy-propionamide |
Type | Small organic molecule |
Emp. Form. | C34H39ClFN5O7S |
Mol. Mass. | 716.219 |
SMILES | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OC(C)(C)C |
Structure |
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