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TargetType-2 angiotensin II receptor
LigandBDBM50030711
Substrate/Competitorn/a
Meas. Tech.ChEMBL_35413 (CHEMBL643587)
IC50 0.12±n/a nM
Citation Chang, LLAshton, WTFlanagan, KLChen, TBO'Malley, SSZingaro, GJKivlighn, SDSiegl, PKLotti, VJChang, RS Potent and orally active angiotensin II receptor antagonists with equal affinity for human AT1 and AT2 subtypes. J Med Chem38:3741-58 (1995) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Type-2 angiotensin II receptor
Name:Type-2 angiotensin II receptor
Synonyms:AGTR2_RAT | AT2 | Agtr2 | Angiotensin II AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Type-2 angiotensin II receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:41346.62
Organism:RAT
Description:Angiotensin II AT2 0 0::P35351
Residue:363
Sequence:
MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFA
VNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVF
GSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFY
FRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLK
TNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLAL
PFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDT
FVS
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  Blast E-value cutoff:
BDBM50030711
n/a
NameBDBM50030711
Synonyms:CHEMBL338027 | L-163958 | Pentanoic acid {4-bromo-3-[3-ethyl-4-(3-fluoro-2'-(N-t-butyloxycarbonyl)-Sulfanamido-biphenyl-4-ylmethyl)-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-phenyl}-amide | Pentanoic acid {4-bromo-3-[3-ethyl-4-(3-fluoro-2'-tert-butyloxycarbonylsulfamoyl-biphenyl-4-ylmethyl)-5-oxo-45-dihydro-[124]triazol-1-yl]-phenyl}-amide(L-163958)
TypeSmall organic molecule
Emp. Form.C33H37BrFN5O6S
Mol. Mass.730.644
SMILESCCCCC(=O)Nc1ccc(Br)c(c1)-n1nc(CC)n(Cc2ccc(cc2F)-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)c1=O
Structure
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